DegronMD - A6NMS7(LRRC37A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1246Y	TCGA-44-6774	LUAD	TCGA	PSTSS	DEG_SPOP_SBC_1	1256:1260	Mutation rewiring degron network	0.0556
p.P1266Q	TCGA-46-3765	LUSC	TCGA	PSTSS	DEG_SPOP_SBC_1	1256:1260	Mutation rewiring degron network	0.1667
p.T1255M	TCGA-A5-A0G2	UCEC	TCGA	PSTSS	DEG_SPOP_SBC_1	1256:1260	Mutation rewiring degron network	0.3056
p.T1255M	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	1256:1260	Mutation rewiring degron network	0.3056
p.T167I	DO51032	LAML	ICGC	QRWSLAEII	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.25
p.T167I	DO51005	LAML	ICGC	QRWSLAEII	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.25
p.T167I	DO229250	THCA	ICGC	QRWSLAEII	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.25
p.F165L	DO52412	UCEC	ICGC	QRWSLAEII	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.3056
p.K1249T	ACH-000021	Lung Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	1256:1260	Mutation substituting flanking lysine	0.25
p.K1249T	ACH-000852	Lung Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	1256:1260	Mutation substituting flanking lysine	0.25
p.I621V	NCI-H2291	lung	COSMIC	LTITPEPT	DEG_SCF_FBW7_1	615:622	Mutation altering degron motif	0.7076

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons