DegronMD

Uniprot ID: A6NMS7

Source protein: Leucine-rich repeat-containing protein 37A

Source gene: LRRC37A

Class: DEG_SCF_FBW7_1

Location: 615:622

E3 ligase: FBXW7

DEGRON score: 0.8835

ASA_SCORE: 93.6

COIL: 0.9604

CONS_SCORE: 0.6033

DSS_SCORE: 0.5952

HELIX: 0.0129

FCONS_SCORE: 0.9667

RIG_SCORE: 0.7013

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I621V	NCI-H2291	lung	COSMIC	LTITPEPT	DEG_SCF_FBW7_1	0.7076

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NM11	Leucine-rich repeat-containing protein 37A2	DEG_SCF_FBW7_1	615:622	LTITPEPT	FBXW7	0.8835	More...
A6NMS7	Leucine-rich repeat-containing protein 37A	DEG_SCF_FBW7_1	615:622	LTITPEPT	FBXW7	0.8835	More...
O60309	Leucine-rich repeat-containing protein 37A3	DEG_SCF_FBW7_1	615:622	LTITPEPT	FBXW7	0.9004	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons