DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
LTITPEPT
Uniprot ID:
A6NM11
Source protein:
Leucine-rich repeat-containing protein 37A2
Source gene:
LRRC37A2
Class:
DEG_SCF_FBW7_1
Location:
615:622
E3 ligase:
FBXW7
DEGRON score:
0.8835
ASA_SCORE:
91.2
COIL:
0.9566
CONS_SCORE:
0.6033
DSS_SCORE:
0.5952
HELIX:
0.0156
FCONS_SCORE:
0.9667
RIG_SCORE:
0.7013
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with LRRC37A2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LTITPEPT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NM11
Leucine-rich repeat-containing protein 37A2
DEG_SCF_FBW7_1
615:622
LTITPEPT
FBXW7
0.8835
More...
A6NMS7
Leucine-rich repeat-containing protein 37A
DEG_SCF_FBW7_1
615:622
LTITPEPT
FBXW7
0.8835
More...
O60309
Leucine-rich repeat-containing protein 37A3
DEG_SCF_FBW7_1
615:622
LTITPEPT
FBXW7
0.9004
More...