DegronMD

Uniprot ID: A6NMS7

Source protein: Leucine-rich repeat-containing protein 37A

Source gene: LRRC37A

Class: DEG_APCC_DBOX_1

Location: 156:164

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9968

ASA_SCORE: 96.8889

COIL: 0.8133

CONS_SCORE: 0.3806

DSS_SCORE: 0.4411

HELIX: 0.1412

FCONS_SCORE: 0.9948

RIG_SCORE: 0.8003

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T167I	DO51032	LAML	ICGC	QRWSLAEII	DEG_APCC_DBOX_1	0.25
p.T167I	DO51005	LAML	ICGC	QRWSLAEII	DEG_APCC_DBOX_1	0.25
p.T167I	DO229250	THCA	ICGC	QRWSLAEII	DEG_APCC_DBOX_1	0.25
p.F165L	DO52412	UCEC	ICGC	QRWSLAEII	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NM11	Leucine-rich repeat-containing protein 37A2	DEG_APCC_DBOX_1	156:164	QRWSLAEII	APC,CDC20,FZR1	0.9733	More...
A6NMS7	Leucine-rich repeat-containing protein 37A	DEG_APCC_DBOX_1	156:164	QRWSLAEII	APC,CDC20,FZR1	0.9968	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons