DegronMD

Uniprot ID: A6NM11

Source protein: Leucine-rich repeat-containing protein 37A2

Source gene: LRRC37A2

Class: DEG_APCC_DBOX_1

Location: 156:164

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9733

ASA_SCORE: 92.5222

COIL: 0.7621

CONS_SCORE: 0.3703

DSS_SCORE: 0.4411

HELIX: 0.1937

FCONS_SCORE: 1.0037

RIG_SCORE: 0.8003

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S171F	TCGA-FI-A2D0	UCEC	TCGA	QRWSLAEII	DEG_APCC_DBOX_1	0.5833
p.S171F	DO43891	UCEC	ICGC	QRWSLAEII	DEG_APCC_DBOX_1	0.5833
p.R168C	TCGA-MA-AA3Z	CESC	TCGA	QRWSLAEII	DEG_APCC_DBOX_1	0.2222
p.R168C	DO219722	CESC	ICGC	QRWSLAEII	DEG_APCC_DBOX_1	0.2222
p.T167I	DO229218	THCA	ICGC	QRWSLAEII	DEG_APCC_DBOX_1	0.25
p.T167I	DO229248	THCA	ICGC	QRWSLAEII	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NM11	Leucine-rich repeat-containing protein 37A2	DEG_APCC_DBOX_1	156:164	QRWSLAEII	APC,CDC20,FZR1	0.9733	More...
A6NMS7	Leucine-rich repeat-containing protein 37A	DEG_APCC_DBOX_1	156:164	QRWSLAEII	APC,CDC20,FZR1	0.9968	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons