DegronMD

Uniprot ID: O60309

Source protein: Leucine-rich repeat-containing protein 37A3

Source gene: LRRC37A3

Class: LIG_APCC_ABBA_1

Location: 106:111

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7588

ASA_SCORE: 83.5167

COIL: 0.9023

CONS_SCORE: 0.4121

DSS_SCORE: 0.6202

HELIX: 0.0577

FCONS_SCORE: 0.9839

RIG_SCORE: 0.7674

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E101K	TCGA-06-5416	GBM	TCGA	LVPFLD	LIG_APCC_ABBA_1	0.1944
p.E101K	DO10880	GBM	ICGC	LVPFLD	LIG_APCC_ABBA_1	0.1944
p.E101K	SW684	soft_tissue	COSMIC	LVPFLD	LIG_APCC_ABBA_1	0.1944
p.A97V	TCGA-2W-A8YY	CESC	TCGA	LVPFLD	LIG_APCC_ABBA_1	0.0833
p.A97V	DO223732	CESC	ICGC	LVPFLD	LIG_APCC_ABBA_1	0.0833
p.L102V	DO569	BLCA	ICGC	LVPFLD	LIG_APCC_ABBA_1	0.2222
p.T116M	DO9708	COAD	ICGC	LVPFLD	LIG_APCC_ABBA_1	0.1944
p.L108F	DO228945	LICA	ICGC	LVPFLD	LIG_APCC_ABBA_1	0.6981
p.P106S	DO228945	LICA	ICGC	LVPFLD	LIG_APCC_ABBA_1	0.6752
p.L117Q	DO228946	LICA	ICGC	LVPFLD	LIG_APCC_ABBA_1	0.1667
p.L117Q	DO229057	LICA	ICGC	LVPFLD	LIG_APCC_ABBA_1	0.1667
p.D99Y	DO229045	LICA	ICGC	LVPFLD	LIG_APCC_ABBA_1	0.1389
p.V118A	DO229047	LICA	ICGC	LVPFLD	LIG_APCC_ABBA_1	0.1389
p.K109N	DO219773	UCEC	ICGC	LVPFLD	LIG_APCC_ABBA_1	0.6918
p.T121I	DO42328	UCEC	ICGC	LVPFLD	LIG_APCC_ABBA_1	0.0556
p.R115Q	COLO-824	breast	COSMIC	LVPFLD	LIG_APCC_ABBA_1	0.2222
p.N108K	MCF7	breast	COSMIC	LVPFLD	LIG_APCC_ABBA_1	0.6918
p.A107V	MDA-MB-453	breast	COSMIC	LVPFLD	LIG_APCC_ABBA_1	0.6936
p.A106V	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	LVPFLD	LIG_APCC_ABBA_1	0.6936
p.E105K	MDA-MB-361	breast	COSMIC	LVPFLD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NM11	Leucine-rich repeat-containing protein 37A2	LIG_APCC_ABBA_1	106:111	LVPFLD	APC,CDC20,FZR1	0.9916	More...
A6NMS7	Leucine-rich repeat-containing protein 37A	LIG_APCC_ABBA_1	106:111	LVPFLD	APC,CDC20,FZR1	0.9907	More...
O60309	Leucine-rich repeat-containing protein 37A3	LIG_APCC_ABBA_1	106:111	LVPFLD	APC,CDC20,FZR1	0.7588	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons