DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LVPFLD
Uniprot ID:
A6NMS7
Source protein:
Leucine-rich repeat-containing protein 37A
Source gene:
LRRC37A
Class:
LIG_APCC_ABBA_1
Location:
106:111
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9907
ASA_SCORE:
81.2333
COIL:
0.8937
CONS_SCORE:
0.4537
DSS_SCORE:
0.6808
HELIX:
0.052
FCONS_SCORE:
1.1984
RIG_SCORE:
0.7573
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with LRRC37A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LVPFLD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NM11
Leucine-rich repeat-containing protein 37A2
LIG_APCC_ABBA_1
106:111
LVPFLD
APC,CDC20,FZR1
0.9916
More...
A6NMS7
Leucine-rich repeat-containing protein 37A
LIG_APCC_ABBA_1
106:111
LVPFLD
APC,CDC20,FZR1
0.9907
More...
O60309
Leucine-rich repeat-containing protein 37A3
LIG_APCC_ABBA_1
106:111
LVPFLD
APC,CDC20,FZR1
0.7588
More...