DegronMD - Q96N64(PWWP2A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R299Q	TCGA-AA-3510	COAD	TCGA	KRKMYRE	LIG_APCC_ABBAyCdc20_2	298:304	Mutation altering degron motif	0.6218
p.R299Q	TCGA-BK-A6W3	UCEC	TCGA	KRKMYRE	LIG_APCC_ABBAyCdc20_2	298:304	Mutation altering degron motif	0.6218
p.R299Q	TCGA-EO-A3B0	UCEC	TCGA	KRKMYRE	LIG_APCC_ABBAyCdc20_2	298:304	Mutation altering degron motif	0.6218
p.R299Q	DO7783	COAD	ICGC	KRKMYRE	LIG_APCC_ABBAyCdc20_2	298:304	Mutation altering degron motif	0.6218
p.R299Q	DO219773	UCEC	ICGC	KRKMYRE	LIG_APCC_ABBAyCdc20_2	298:304	Mutation altering degron motif	0.6218
p.R299Q	DO50076	UCEC	ICGC	KRKMYRE	LIG_APCC_ABBAyCdc20_2	298:304	Mutation altering degron motif	0.6218
p.R299Q	SIDM00781	Colorectal Carcinoma	GDSC	KRKMYRE	LIG_APCC_ABBAyCdc20_2	298:304	Mutation altering degron motif	0.6218
p.R299Q	SIDM00780	Colorectal Carcinoma	GDSC	KRKMYRE	LIG_APCC_ABBAyCdc20_2	298:304	Mutation altering degron motif	0.6218
p.R299Q	ACH-000967	Colon/Colorectal Cancer	CCLE	KRKMYRE	LIG_APCC_ABBAyCdc20_2	298:304	Mutation altering degron motif	0.6218
p.R299Q	ACH-001199	Colon/Colorectal Cancer	CCLE	KRKMYRE	LIG_APCC_ABBAyCdc20_2	298:304	Mutation altering degron motif	0.6218
p.R299Q	SNU-C2B	large intestine	COSMIC	KRKMYRE	LIG_APCC_ABBAyCdc20_2	298:304	Mutation altering degron motif	0.6218
p.E305K	TCGA-AZ-4315	COAD	TCGA	KRKMYRE	LIG_APCC_ABBAyCdc20_2	298:304	Mutation rewiring degron network	0.3056
p.E305K	DO8842	COAD	ICGC	KRKMYRE	LIG_APCC_ABBAyCdc20_2	298:304	Mutation rewiring degron network	0.3056
p.E626D	TCGA-EO-A22X	UCEC	TCGA	APSTS	DEG_SPOP_SBC_1	613:617	Mutation rewiring degron network	0.0833
p.E626D	DO222798	COCA	ICGC	APSTS	DEG_SPOP_SBC_1	613:617	Mutation rewiring degron network	0.0833
p.E626D	DO43907	UCEC	ICGC	APSTS	DEG_SPOP_SBC_1	613:617	Mutation rewiring degron network	0.0833
p.Q288E	TCGA-IR-A3LH	CESC	TCGA	KRKMYRE	LIG_APCC_ABBAyCdc20_2	298:304	Mutation rewiring degron network	0.0556
p.Q288E	DO44381	CESC	ICGC	KRKMYRE	LIG_APCC_ABBAyCdc20_2	298:304	Mutation rewiring degron network	0.0556
p.S620P	TCGA-UZ-A9PX	KIRP	TCGA	APSTS	DEG_SPOP_SBC_1	613:617	Mutation rewiring degron network	0.25
p.S620P	DO219712	KIRP	ICGC	APSTS	DEG_SPOP_SBC_1	613:617	Mutation rewiring degron network	0.25
p.R292Q	DO234151	ESAD	ICGC	KRKMYRE	LIG_APCC_ABBAyCdc20_2	298:304	Mutation rewiring degron network	0.1667
p.R292W	DO233949	GACA	ICGC	KRKMYRE	LIG_APCC_ABBAyCdc20_2	298:304	Mutation rewiring degron network	0.1667
p.F604S	DO233952	GACA	ICGC	APSTS	DEG_SPOP_SBC_1	613:617	Mutation rewiring degron network	0.0833
p.P289Q	DO229041	LICA	ICGC	KRKMYRE	LIG_APCC_ABBAyCdc20_2	298:304	Mutation rewiring degron network	0.0833
p.E625K	DO231057	LUSC	ICGC	APSTS	DEG_SPOP_SBC_1	613:617	Mutation rewiring degron network	0.1111
p.D605A	DO232224	PBCA	ICGC	APSTS	DEG_SPOP_SBC_1	613:617	Mutation rewiring degron network	0.1111
p.K627R	SIDM00362	Burkitt's Lymphoma	GDSC	APSTS	DEG_SPOP_SBC_1	613:617	Mutation substituting flanking lysine	0.1667

Kaplan plot for PWWP2A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PWWP2A

UniProt ID: Q96N64

Entrez ID: 114825

Protein name: PWWP domain-containing protein 2A

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PWWP2A in