DegronMD

Uniprot ID: Q96N64

Source protein: PWWP domain-containing protein 2A

Source gene: PWWP2A

Class: LIG_APCC_ABBAyCdc20_2

Location: 298:304

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9865

ASA_SCORE: 142.7429

COIL: 0.7813

CONS_SCORE: 0.4874

DSS_SCORE: 0.6415

HELIX: 0.2241

FCONS_SCORE: 0.9965

RIG_SCORE: 0.7145

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R299Q	TCGA-AA-3510	COAD	TCGA	KRKMYRE	LIG_APCC_ABBAyCdc20_2	0.6218
p.R299Q	TCGA-BK-A6W3	UCEC	TCGA	KRKMYRE	LIG_APCC_ABBAyCdc20_2	0.6218
p.R299Q	TCGA-EO-A3B0	UCEC	TCGA	KRKMYRE	LIG_APCC_ABBAyCdc20_2	0.6218
p.R299Q	DO7783	COAD	ICGC	KRKMYRE	LIG_APCC_ABBAyCdc20_2	0.6218
p.R299Q	DO219773	UCEC	ICGC	KRKMYRE	LIG_APCC_ABBAyCdc20_2	0.6218
p.R299Q	DO50076	UCEC	ICGC	KRKMYRE	LIG_APCC_ABBAyCdc20_2	0.6218
p.R299Q	SIDM00781	Colorectal Carcinoma	GDSC	KRKMYRE	LIG_APCC_ABBAyCdc20_2	0.6218
p.R299Q	SIDM00780	Colorectal Carcinoma	GDSC	KRKMYRE	LIG_APCC_ABBAyCdc20_2	0.6218
p.R299Q	ACH-000967	Colon/Colorectal Cancer	CCLE	KRKMYRE	LIG_APCC_ABBAyCdc20_2	0.6218
p.R299Q	ACH-001199	Colon/Colorectal Cancer	CCLE	KRKMYRE	LIG_APCC_ABBAyCdc20_2	0.6218
p.R299Q	SNU-C2B	large_intestine	COSMIC	KRKMYRE	LIG_APCC_ABBAyCdc20_2	0.6218
p.E305K	TCGA-AZ-4315	COAD	TCGA	KRKMYRE	LIG_APCC_ABBAyCdc20_2	0.3056
p.E305K	DO8842	COAD	ICGC	KRKMYRE	LIG_APCC_ABBAyCdc20_2	0.3056
p.Q288E	TCGA-IR-A3LH	CESC	TCGA	KRKMYRE	LIG_APCC_ABBAyCdc20_2	0.0556
p.Q288E	DO44381	CESC	ICGC	KRKMYRE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R292Q	DO234151	ESAD	ICGC	KRKMYRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R292W	DO233949	GACA	ICGC	KRKMYRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.P289Q	DO229041	LICA	ICGC	KRKMYRE	LIG_APCC_ABBAyCdc20_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96N64	PWWP domain-containing protein 2A	LIG_APCC_ABBAyCdc20_2	298:304	KRKMYRE	APC,CDC20,FZR1	0.9865	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons