DegronMD - O75962(TRIO)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E2285K	TCGA-4Z-AA7M	BLCA	TCGA	QRNFLNALT	DEG_APCC_DBOX_1	2273:2281	Mutation rewiring degron network	0.2222
p.E2285K	DO218976	BLCA	ICGC	QRNFLNALT	DEG_APCC_DBOX_1	2273:2281	Mutation rewiring degron network	0.2222
p.E2285K	DO229268	THCA	ICGC	QRNFLNALT	DEG_APCC_DBOX_1	2273:2281	Mutation rewiring degron network	0.2222
p.P2344S	TCGA-63-A5MJ	LUSC	TCGA	APSTS	DEG_SPOP_SBC_1	2330:2334	Mutation rewiring degron network	0.0556
p.P2344S	DO219149	LUSC	ICGC	APSTS	DEG_SPOP_SBC_1	2330:2334	Mutation rewiring degron network	0.0556
p.P518S	TCGA-96-A4JK	LUSC	TCGA	PLTPGSS	DEG_SCF_FBW7_1	515:521	Mutation altering degron motif	0.6752
p.P518S	DO45442	LUSC	ICGC	PLTPGSS	DEG_SCF_FBW7_1	515:521	Mutation altering degron motif	0.6752
p.G519S	TCGA-96-A4JK	LUSC	TCGA	PLTPGSS	DEG_SCF_FBW7_1	515:521	Mutation altering degron motif	0.5882
p.G519S	DO45442	LUSC	ICGC	PLTPGSS	DEG_SCF_FBW7_1	515:521	Mutation altering degron motif	0.5882
p.G519S	SIDM01749	Osteosarcoma	GDSC	PLTPGSS	DEG_SCF_FBW7_1	515:521	Mutation altering degron motif	0.5882
p.G519S	ACH-000340	Non-Cancerous	CCLE	PLTPGSS	DEG_SCF_FBW7_1	515:521	Mutation altering degron motif	0.5882
p.R2438C	TCGA-A6-6781	COAD	TCGA	ARASLGTLP	DEG_APCC_DBOX_1	2437:2445	Mutation altering degron motif	0.8301
p.R2438C	DO8447	COAD	ICGC	ARASLGTLP	DEG_APCC_DBOX_1	2437:2445	Mutation altering degron motif	0.8301
p.N2275T	TCGA-AJ-A5DW	UCEC	TCGA	QRNFLNALT	DEG_APCC_DBOX_1	2273:2281	Mutation altering degron motif	0.5944
p.N2275T	DO50075	UCEC	ICGC	QRNFLNALT	DEG_APCC_DBOX_1	2273:2281	Mutation altering degron motif	0.5944
p.P515S	TCGA-BG-A222	UCEC	TCGA	PLTPGSS	DEG_SCF_FBW7_1	515:521	Mutation altering degron motif	0.6752
p.P515S	DO42977	UCEC	ICGC	PLTPGSS	DEG_SCF_FBW7_1	515:521	Mutation altering degron motif	0.6752
p.N2275K	TCGA-CA-6717	COAD	TCGA	QRNFLNALT	DEG_APCC_DBOX_1	2273:2281	Mutation altering degron motif	0.5806
p.N2275K	DO8264	COAD	ICGC	QRNFLNALT	DEG_APCC_DBOX_1	2273:2281	Mutation altering degron motif	0.5806
p.S2282L	TCGA-EB-A431	SKCM	TCGA	QRNFLNALT	DEG_APCC_DBOX_1	2273:2281	Mutation blocking phosphorylation signal	0.75
p.S2282L	DO231816	LINC	ICGC	QRNFLNALT	DEG_APCC_DBOX_1	2273:2281	Mutation blocking phosphorylation signal	0.75
p.S2282L	DO37671	SKCM	ICGC	QRNFLNALT	DEG_APCC_DBOX_1	2273:2281	Mutation blocking phosphorylation signal	0.75
p.Q2287H	TCGA-EE-A29X	SKCM	TCGA	QRNFLNALT	DEG_APCC_DBOX_1	2273:2281	Mutation rewiring degron network	0.1667
p.Q2287H	DO37595	SKCM	ICGC	QRNFLNALT	DEG_APCC_DBOX_1	2273:2281	Mutation rewiring degron network	0.1667
p.F2276L	TCGA-IB-7651	PAAD	TCGA	QRNFLNALT	DEG_APCC_DBOX_1	2273:2281	Mutation altering degron motif	0.587
p.F2276L	DO46657	PAAD	ICGC	QRNFLNALT	DEG_APCC_DBOX_1	2273:2281	Mutation altering degron motif	0.587
p.N2289K	TCGA-N8-A4PO	UCS	TCGA	QRNFLNALT	DEG_APCC_DBOX_1	2273:2281	Mutation rewiring degron network	0.1111
p.D2447Y	DO52711	CLLE	ICGC	ARASLGTLP	DEG_APCC_DBOX_1	2437:2445	Mutation rewiring degron network	0.2778
p.R2274H	DO222840	COCA	ICGC	QRNFLNALT	DEG_APCC_DBOX_1	2273:2281	Mutation altering degron motif	0.8244
p.R2274H	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	QRNFLNALT	DEG_APCC_DBOX_1	2273:2281	Mutation altering degron motif	0.8244
p.R2274H	H513	pleura	COSMIC	QRNFLNALT	DEG_APCC_DBOX_1	2273:2281	Mutation altering degron motif	0.8244
p.A2451T	DO233254	GACA	ICGC	ARASLGTLP	DEG_APCC_DBOX_1	2437:2445	Mutation rewiring degron network	0.1667
p.A2451T	DO233254	GACA	ICGC	SPLSSAVPSL	DEG_COP1_1	2459:2468	Mutation rewiring degron network	0.1111
p.Q2273H	DO233282	GACA	ICGC	QRNFLNALT	DEG_APCC_DBOX_1	2273:2281	Mutation altering degron motif	0.647
p.S2463I	DO49666	LIAD	ICGC	SPLSSAVPSL	DEG_COP1_1	2459:2468	Mutation altering degron motif	0.623
p.R2461C	DO23380	LINC	ICGC	SPLSSAVPSL	DEG_COP1_1	2459:2468	Mutation altering degron motif	0.8301
p.A2279T	DO229172	LMS	ICGC	QRNFLNALT	DEG_APCC_DBOX_1	2273:2281	Mutation altering degron motif	0.6028
p.A2437V	DO228438	MALY	ICGC	ARASLGTLP	DEG_APCC_DBOX_1	2437:2445	Mutation altering degron motif	0.5825
p.A2437T	DO228880	MALY	ICGC	ARASLGTLP	DEG_APCC_DBOX_1	2437:2445	Mutation altering degron motif	0.6028
p.S2455L	DO220882	MELA	ICGC	ARASLGTLP	DEG_APCC_DBOX_1	2437:2445	Mutation blocking phosphorylation signal	0.5
p.S2455L	DO220882	MELA	ICGC	SPLSSAVPSL	DEG_COP1_1	2459:2468	Mutation blocking phosphorylation signal	0.6667
p.S2455L	DO222702	MELA	ICGC	ARASLGTLP	DEG_APCC_DBOX_1	2437:2445	Mutation blocking phosphorylation signal	0.5
p.S2455L	DO222702	MELA	ICGC	SPLSSAVPSL	DEG_COP1_1	2459:2468	Mutation blocking phosphorylation signal	0.6667
p.A2454S	DO229264	THCA	ICGC	ARASLGTLP	DEG_APCC_DBOX_1	2437:2445	Mutation rewiring degron network	0.0833
p.A2454S	DO229264	THCA	ICGC	SPLSSAVPSL	DEG_COP1_1	2459:2468	Mutation rewiring degron network	0.1944
p.P2433H	DO229268	THCA	ICGC	ARASLGTLP	DEG_APCC_DBOX_1	2437:2445	Mutation rewiring degron network	0.2222
p.L2435M	DO229275	THCA	ICGC	ARASLGTLP	DEG_APCC_DBOX_1	2437:2445	Mutation rewiring degron network	0.2778
p.S2462C	DO43162	UCEC	ICGC	SPLSSAVPSL	DEG_COP1_1	2459:2468	Mutation altering degron motif	0.8652
p.S507L	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PLTPGSS	DEG_SCF_FBW7_1	515:521	Mutation rewiring degron network	0.1111
p.S507L	ACH-000981	Leukemia	CCLE	PLTPGSS	DEG_SCF_FBW7_1	515:521	Mutation rewiring degron network	0.1111
p.S507L	DND-41	haematopoietic and lymphoid tissue	COSMIC	PLTPGSS	DEG_SCF_FBW7_1	515:521	Mutation rewiring degron network	0.1111
p.A2464V	SIDM00216	Colorectal Carcinoma	GDSC	SPLSSAVPSL	DEG_COP1_1	2459:2468	Mutation altering degron motif	0.5825
p.L2446F	SIDM00614	Hepatocellular Carcinoma	GDSC	ARASLGTLP	DEG_APCC_DBOX_1	2437:2445	Mutation rewiring degron network	0.3056
p.L2446F	ACH-000321	Leukemia	CCLE	ARASLGTLP	DEG_APCC_DBOX_1	2437:2445	Mutation rewiring degron network	0.3056
p.L2446F	ACH-000848	Liver Cancer	CCLE	ARASLGTLP	DEG_APCC_DBOX_1	2437:2445	Mutation rewiring degron network	0.3056
p.P2475A	SIDM00553	Acute Myeloid Leukemia	GDSC	SPLSSAVPSL	DEG_COP1_1	2459:2468	Mutation rewiring degron network	0.1389
p.P2475A	ACH-002262	Leukemia	CCLE	SPLSSAVPSL	DEG_COP1_1	2459:2468	Mutation rewiring degron network	0.1389
p.P2475A	KY821	haematopoietic and lymphoid tissue	COSMIC	SPLSSAVPSL	DEG_COP1_1	2459:2468	Mutation rewiring degron network	0.1389
p.P2445S	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	ARASLGTLP	DEG_APCC_DBOX_1	2437:2445	Mutation altering degron motif	0.5641
p.P2445S	ACH-000865	Esophageal Cancer	CCLE	ARASLGTLP	DEG_APCC_DBOX_1	2437:2445	Mutation altering degron motif	0.5641
p.P2445S	ACH-000994	Endometrial/Uterine Cancer	CCLE	ARASLGTLP	DEG_APCC_DBOX_1	2437:2445	Mutation altering degron motif	0.5641
p.A2279V	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	QRNFLNALT	DEG_APCC_DBOX_1	2273:2281	Mutation altering degron motif	0.5825
p.A2279V	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	QRNFLNALT	DEG_APCC_DBOX_1	2273:2281	Mutation altering degron motif	0.5825
p.G2452A	SIDM00100	Mesothelioma	GDSC	ARASLGTLP	DEG_APCC_DBOX_1	2437:2445	Mutation rewiring degron network	0.1389
p.G2452A	SIDM00100	Mesothelioma	GDSC	SPLSSAVPSL	DEG_COP1_1	2459:2468	Mutation rewiring degron network	0.1389
p.P2475T	SIDM01545	Non-Small Cell Lung Carcinoma	GDSC	SPLSSAVPSL	DEG_COP1_1	2459:2468	Mutation rewiring degron network	0.1389
p.P2475T	ACH-000511	Lung Cancer	CCLE	SPLSSAVPSL	DEG_COP1_1	2459:2468	Mutation rewiring degron network	0.1389
p.P2466S	ACH-000873	Esophageal Cancer	CCLE	SPLSSAVPSL	DEG_COP1_1	2459:2468	Mutation altering degron motif	0.6752
p.F2473S	ACH-000987	Skin Cancer	CCLE	SPLSSAVPSL	DEG_COP1_1	2459:2468	Mutation rewiring degron network	0.1944
p.L2444P	ACH-000990	Endometrial/Uterine Cancer	CCLE	ARASLGTLP	DEG_APCC_DBOX_1	2437:2445	Mutation altering degron motif	0.7582
p.R509C	CCK-81	large intestine	COSMIC	PLTPGSS	DEG_SCF_FBW7_1	515:521	Mutation rewiring degron network	0.1667
p.E524K	NCI-H2110	lung	COSMIC	PLTPGSS	DEG_SCF_FBW7_1	515:521	Mutation rewiring degron network	0.25
p.R2274C	NCI-H630	large intestine	COSMIC	QRNFLNALT	DEG_APCC_DBOX_1	2273:2281	Mutation altering degron motif	0.8301

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRIO

UniProt ID: O75962

Entrez ID: 7204

Protein name: Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRIO in