DegronMD

Uniprot ID: O75962

Source protein: Triple functional domain protein

Source gene: TRIO

Class: DEG_COP1_1

Location: 2459:2468

E3 ligase: COP1

DEGRON score: 0.9969

ASA_SCORE: 65.89

COIL: 0.8483

CONS_SCORE: 0.2709

DSS_SCORE: 0.5336

HELIX: 0.0864

FCONS_SCORE: 1.0438

RIG_SCORE: 0.6225

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2451T	DO233254	GACA	ICGC	SPLSSAVPSL	DEG_COP1_1	0.1111
p.S2463I	DO49666	LIAD	ICGC	SPLSSAVPSL	DEG_COP1_1	0.623
p.R2461C	DO23380	LINC	ICGC	SPLSSAVPSL	DEG_COP1_1	0.8301
p.S2455L	DO220882	MELA	ICGC	SPLSSAVPSL	DEG_COP1_1	0.6667
p.S2455L	DO222702	MELA	ICGC	SPLSSAVPSL	DEG_COP1_1	0.6667
p.A2454S	DO229264	THCA	ICGC	SPLSSAVPSL	DEG_COP1_1	0.1944
p.S2462C	DO43162	UCEC	ICGC	SPLSSAVPSL	DEG_COP1_1	0.8652
p.A2464V	SIDM00216	Colorectal Carcinoma	GDSC	SPLSSAVPSL	DEG_COP1_1	0.5825
p.P2475A	SIDM00553	Acute Myeloid Leukemia	GDSC	SPLSSAVPSL	DEG_COP1_1	0.1389
p.P2475A	ACH-002262	Leukemia	CCLE	SPLSSAVPSL	DEG_COP1_1	0.1389
p.P2475A	KY821	haematopoietic_and_lymphoid_tissue	COSMIC	SPLSSAVPSL	DEG_COP1_1	0.1389
p.G2452A	SIDM00100	Mesothelioma	GDSC	SPLSSAVPSL	DEG_COP1_1	0.1389
p.P2475T	SIDM01545	Non-Small Cell Lung Carcinoma	GDSC	SPLSSAVPSL	DEG_COP1_1	0.1389
p.P2475T	ACH-000511	Lung Cancer	CCLE	SPLSSAVPSL	DEG_COP1_1	0.1389
p.P2466S	ACH-000873	Esophageal Cancer	CCLE	SPLSSAVPSL	DEG_COP1_1	0.6752
p.F2473S	ACH-000987	Skin Cancer	CCLE	SPLSSAVPSL	DEG_COP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75962	Triple functional domain protein	DEG_COP1_1	2459:2468	SPLSSAVPSL	COP1	0.9969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons