DegronMD

Uniprot ID: O75962

Source protein: Triple functional domain protein

Source gene: TRIO

Class: DEG_SCF_FBW7_1

Location: 515:521

E3 ligase: FBXW7

DEGRON score: 0.6508

ASA_SCORE: 69.3

COIL: 0.9281

CONS_SCORE: 0.3264

DSS_SCORE: 0.4407

HELIX: 0.0466

FCONS_SCORE: 0.8262

RIG_SCORE: 0.6541

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P518S	TCGA-96-A4JK	LUSC	TCGA	PLTPGSS	DEG_SCF_FBW7_1	0.6752
p.P518S	DO45442	LUSC	ICGC	PLTPGSS	DEG_SCF_FBW7_1	0.6752
p.G519S	TCGA-96-A4JK	LUSC	TCGA	PLTPGSS	DEG_SCF_FBW7_1	0.5882
p.G519S	DO45442	LUSC	ICGC	PLTPGSS	DEG_SCF_FBW7_1	0.5882
p.G519S	SIDM01749	Osteosarcoma	GDSC	PLTPGSS	DEG_SCF_FBW7_1	0.5882
p.G519S	ACH-000340	Non-Cancerous	CCLE	PLTPGSS	DEG_SCF_FBW7_1	0.5882
p.P515S	TCGA-BG-A222	UCEC	TCGA	PLTPGSS	DEG_SCF_FBW7_1	0.6752
p.P515S	DO42977	UCEC	ICGC	PLTPGSS	DEG_SCF_FBW7_1	0.6752
p.S507L	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PLTPGSS	DEG_SCF_FBW7_1	0.1111
p.S507L	ACH-000981	Leukemia	CCLE	PLTPGSS	DEG_SCF_FBW7_1	0.1111
p.S507L	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PLTPGSS	DEG_SCF_FBW7_1	0.1111
p.R509C	CCK-81	large_intestine	COSMIC	PLTPGSS	DEG_SCF_FBW7_1	0.1667
p.E524K	NCI-H2110	lung	COSMIC	PLTPGSS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75962	Triple functional domain protein	DEG_SCF_FBW7_1	515:521	PLTPGSS	FBXW7	0.6508	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons