DegronMD

Uniprot ID: O75962

Source protein: Triple functional domain protein

Source gene: TRIO

Class: DEG_APCC_DBOX_1

Location: 2437:2445

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9141

ASA_SCORE: 72.4556

COIL: 0.7401

CONS_SCORE: 0.2188

DSS_SCORE: 0.6068

HELIX: 0.1752

FCONS_SCORE: 0.8906

RIG_SCORE: 0.663

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2438C	TCGA-A6-6781	COAD	TCGA	ARASLGTLP	DEG_APCC_DBOX_1	0.8301
p.R2438C	DO8447	COAD	ICGC	ARASLGTLP	DEG_APCC_DBOX_1	0.8301
p.D2447Y	DO52711	CLLE	ICGC	ARASLGTLP	DEG_APCC_DBOX_1	0.2778
p.A2451T	DO233254	GACA	ICGC	ARASLGTLP	DEG_APCC_DBOX_1	0.1667
p.A2437V	DO228438	MALY	ICGC	ARASLGTLP	DEG_APCC_DBOX_1	0.5825
p.A2437T	DO228880	MALY	ICGC	ARASLGTLP	DEG_APCC_DBOX_1	0.6028
p.S2455L	DO220882	MELA	ICGC	ARASLGTLP	DEG_APCC_DBOX_1	0.5
p.S2455L	DO222702	MELA	ICGC	ARASLGTLP	DEG_APCC_DBOX_1	0.5
p.A2454S	DO229264	THCA	ICGC	ARASLGTLP	DEG_APCC_DBOX_1	0.0833
p.P2433H	DO229268	THCA	ICGC	ARASLGTLP	DEG_APCC_DBOX_1	0.2222
p.L2435M	DO229275	THCA	ICGC	ARASLGTLP	DEG_APCC_DBOX_1	0.2778
p.L2446F	SIDM00614	Hepatocellular Carcinoma	GDSC	ARASLGTLP	DEG_APCC_DBOX_1	0.3056
p.L2446F	ACH-000321	Leukemia	CCLE	ARASLGTLP	DEG_APCC_DBOX_1	0.3056
p.L2446F	ACH-000848	Liver Cancer	CCLE	ARASLGTLP	DEG_APCC_DBOX_1	0.3056
p.P2445S	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	ARASLGTLP	DEG_APCC_DBOX_1	0.5641
p.P2445S	ACH-000865	Esophageal Cancer	CCLE	ARASLGTLP	DEG_APCC_DBOX_1	0.5641
p.P2445S	ACH-000994	Endometrial/Uterine Cancer	CCLE	ARASLGTLP	DEG_APCC_DBOX_1	0.5641
p.G2452A	SIDM00100	Mesothelioma	GDSC	ARASLGTLP	DEG_APCC_DBOX_1	0.1389
p.L2444P	ACH-000990	Endometrial/Uterine Cancer	CCLE	ARASLGTLP	DEG_APCC_DBOX_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75962	Triple functional domain protein	DEG_APCC_DBOX_1	2437:2445	ARASLGTLP	APC,CDC20,FZR1	0.9141	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons