DegronMD

Uniprot ID: O75962

Source protein: Triple functional domain protein

Source gene: TRIO

Class: DEG_APCC_DBOX_1

Location: 2273:2281

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8381

ASA_SCORE: 57.7667

COIL: 0.2082

CONS_SCORE: 0.5142

DSS_SCORE: 0.3684

HELIX: 0.7658

FCONS_SCORE: 1.2361

RIG_SCORE: 0.8292

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E2285K	TCGA-4Z-AA7M	BLCA	TCGA	QRNFLNALT	DEG_APCC_DBOX_1	0.2222
p.E2285K	DO218976	BLCA	ICGC	QRNFLNALT	DEG_APCC_DBOX_1	0.2222
p.E2285K	DO229268	THCA	ICGC	QRNFLNALT	DEG_APCC_DBOX_1	0.2222
p.N2275T	TCGA-AJ-A5DW	UCEC	TCGA	QRNFLNALT	DEG_APCC_DBOX_1	0.5944
p.N2275T	DO50075	UCEC	ICGC	QRNFLNALT	DEG_APCC_DBOX_1	0.5944
p.N2275K	TCGA-CA-6717	COAD	TCGA	QRNFLNALT	DEG_APCC_DBOX_1	0.5806
p.N2275K	DO8264	COAD	ICGC	QRNFLNALT	DEG_APCC_DBOX_1	0.5806
p.S2282L	TCGA-EB-A431	SKCM	TCGA	QRNFLNALT	DEG_APCC_DBOX_1	0.75
p.S2282L	DO231816	LINC	ICGC	QRNFLNALT	DEG_APCC_DBOX_1	0.75
p.S2282L	DO37671	SKCM	ICGC	QRNFLNALT	DEG_APCC_DBOX_1	0.75
p.Q2287H	TCGA-EE-A29X	SKCM	TCGA	QRNFLNALT	DEG_APCC_DBOX_1	0.1667
p.Q2287H	DO37595	SKCM	ICGC	QRNFLNALT	DEG_APCC_DBOX_1	0.1667
p.F2276L	TCGA-IB-7651	PAAD	TCGA	QRNFLNALT	DEG_APCC_DBOX_1	0.587
p.F2276L	DO46657	PAAD	ICGC	QRNFLNALT	DEG_APCC_DBOX_1	0.587
p.N2289K	TCGA-N8-A4PO	UCS	TCGA	QRNFLNALT	DEG_APCC_DBOX_1	0.1111
p.R2274H	DO222840	COCA	ICGC	QRNFLNALT	DEG_APCC_DBOX_1	0.8244
p.R2274H	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	QRNFLNALT	DEG_APCC_DBOX_1	0.8244
p.R2274H	H513	pleura	COSMIC	QRNFLNALT	DEG_APCC_DBOX_1	0.8244
p.Q2273H	DO233282	GACA	ICGC	QRNFLNALT	DEG_APCC_DBOX_1	0.647
p.A2279T	DO229172	LMS	ICGC	QRNFLNALT	DEG_APCC_DBOX_1	0.6028
p.A2279V	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	QRNFLNALT	DEG_APCC_DBOX_1	0.5825
p.A2279V	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	QRNFLNALT	DEG_APCC_DBOX_1	0.5825
p.R2274C	NCI-H630	large_intestine	COSMIC	QRNFLNALT	DEG_APCC_DBOX_1	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75962	Triple functional domain protein	DEG_APCC_DBOX_1	2273:2281	QRNFLNALT	APC,CDC20,FZR1	0.8381	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons