DegronMD - Q96QF0(RAB3IP)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T268M	TCGA-4R-AA8I	LIHC	TCGA	VLSSS	DEG_SPOP_SBC_1	259:263	Mutation blocking phosphorylation signal	0.6389
p.T268M	TCGA-EA-A410	CESC	TCGA	VLSSS	DEG_SPOP_SBC_1	259:263	Mutation blocking phosphorylation signal	0.6389
p.G117R	TCGA-91-7771	LUAD	TCGA	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.1944
p.D105Y	TCGA-94-A4VJ	LUSC	TCGA	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.25
p.P264T	TCGA-A6-6653	COAD	TCGA	VLSSS	DEG_SPOP_SBC_1	259:263	Mutation rewiring degron network	0.3056
p.P273S	TCGA-AP-A1DK	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	259:263	Mutation rewiring degron network	0.0556
p.T257I	TCGA-AX-A1CE	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	259:263	Mutation rewiring degron network	0.2778
p.V252L	TCGA-AX-A2HC	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	259:263	Mutation rewiring degron network	0.1389
p.K256N	TCGA-B5-A3FC	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	259:263	Mutation substituting flanking lysine	0.3611
p.P267S	TCGA-EE-A2GO	SKCM	TCGA	VLSSS	DEG_SPOP_SBC_1	259:263	Mutation rewiring degron network	0.2222
p.T111A	TCGA-GU-A42P	BLCA	TCGA	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation altering degron motif	0.7139
p.D105H	TCGA-NK-A5CT	LUSC	TCGA	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.25
p.E251Q	TCGA-VS-A958	CESC	TCGA	VLSSS	DEG_SPOP_SBC_1	259:263	Mutation rewiring degron network	0.1111
p.P267L	TCGA-WE-A8ZT	SKCM	TCGA	VLSSS	DEG_SPOP_SBC_1	259:263	Mutation rewiring degron network	0.2222
p.K100I	DO219087	BLCA	ICGC	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.1111
p.S111C	DO52478	COCA	ICGC	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation altering degron motif	0.7541
p.I110T	DO10880	GBM	ICGC	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation altering degron motif	0.7078
p.Y108S	DO15743	HNSC	ICGC	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation altering degron motif	0.712
p.G258C	DO229029	LICA	ICGC	VLSSS	DEG_SPOP_SBC_1	259:263	Mutation rewiring degron network	0.3056
p.V98F	DO229028	LICA	ICGC	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.0556
p.C122F	DO229032	LICA	ICGC	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.0556
p.A122T	DO229050	LICA	ICGC	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.0556
p.R115K	DO229059	LICA	ICGC	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation blocking phosphorylation signal	0.6944
p.R98K	DO44887	LIHC	ICGC	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.0556
p.G101R	DO25807	LUAD	ICGC	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.1389
p.R117S	DO37707	SKCM	ICGC	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.1944
p.R98I	DO41752	UCEC	ICGC	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.0556
p.R98I	DO43907	UCEC	ICGC	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.0556
p.R269I	DO42400	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	259:263	Mutation rewiring degron network	0.1667
p.T265A	SIDM00499	Prostate Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	259:263	Mutation blocking phosphorylation signal	0.7222
p.T265A	22RV1	prostate	COSMIC	VLSSS	DEG_SPOP_SBC_1	259:263	Mutation blocking phosphorylation signal	0.7222
p.I99V	SIDM00473	Oral Cavity Carcinoma	GDSC	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.0833
p.I99V	PE/CA-PJ15	upper aerodigestive tract	COSMIC	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.0833
p.S263F	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	VLSSS	DEG_SPOP_SBC_1	259:263	Mutation altering degron motif	0.9093
p.S263F	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	VLSSS	DEG_SPOP_SBC_1	259:263	Mutation altering degron motif	0.9093
p.V259A	SIDM01100	Neuroblastoma	GDSC	VLSSS	DEG_SPOP_SBC_1	259:263	Mutation altering degron motif	0.5825
p.V259A	SK-N-DZ	autonomic ganglia	COSMIC	VLSSS	DEG_SPOP_SBC_1	259:263	Mutation altering degron motif	0.5825
p.S262N	SIDM00079	Ovarian Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	259:263	Mutation altering degron motif	0.818
p.S262N	SK-OV-3	ovary	COSMIC	VLSSS	DEG_SPOP_SBC_1	259:263	Mutation altering degron motif	0.818
p.V103G	SIDM00118	Colorectal Carcinoma	GDSC	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.1944
p.V103G	HCC2998	large intestine	COSMIC	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.1944
p.H102R	SIDM00164	Biliary Tract Carcinoma	GDSC	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.1667
p.K109N	ACH-000593	Bladder Cancer	CCLE	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation altering degron motif	0.6918
p.T249A	ACH-000956	Prostate Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	259:263	Mutation rewiring degron network	0.0556
p.T249A	22RV1	prostate	COSMIC	VLSSS	DEG_SPOP_SBC_1	259:263	Mutation rewiring degron network	0.0556
p.Y108H	SNG-M	endometrium	COSMIC	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation altering degron motif	0.7229
p.K264I	NCC021	kidney	COSMIC	VLSSS	DEG_SPOP_SBC_1	259:263	Mutation rewiring degron network	0.3056
p.V121A	SK-MEL-2	skin	COSMIC	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.0833
p.K100T	RERF-LC-FM	lung	COSMIC	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.1111
p.K100T	HuP-T4	pancreas	COSMIC	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.1111
p.K100T	TALL-1	haematopoietic and lymphoid tissue	COSMIC	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.1111
p.K100T	KP-2	pancreas	COSMIC	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.1111
p.K100T	HSC-3	upper aerodigestive tract	COSMIC	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.1111
p.K100T	RERF-LC-KJ	lung	COSMIC	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.1111
p.K100T	NKM-1	haematopoietic and lymphoid tissue	COSMIC	PCSTS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.1111

Kaplan plot for RAB3IP in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RAB3IP

UniProt ID: Q96QF0

Entrez ID: 117177

Protein name: Rab-3A-interacting protein (Rab3A-interacting protein) (Rabin-3) (SSX2-interacting protein)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for RAB3IP in