DegronMD - P17813(ENG)

GO - Biological processes (BP): artery morphogenesis [GO:0048844]; atrial cardiac muscle tissue morphogenesis [GO:0055009]; atrioventricular canal morphogenesis [GO:1905222]; BMP signaling pathway [GO:0030509]; bone development [GO:0060348]; branching involved in blood vessel morphogenesis [GO:0001569]; cardiac atrium morphogenesis [GO:0003209]; cardiac ventricle morphogenesis [GO:0003208]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; cell migration involved in endocardial cushion formation [GO:0003273]; cell motility [GO:0048870]; cellular response to mechanical stimulus [GO:0071260]; central nervous system vasculogenesis [GO:0022009]; detection of hypoxia [GO:0070483]; dorsal aorta morphogenesis [GO:0035912]; endocardial cushion morphogenesis [GO:0003203]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; extracellular matrix constituent secretion [GO:0070278]; extracellular matrix disassembly [GO:0022617]; heart looping [GO:0001947]; negative regulation of cell migration [GO:0030336]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of gene expression [GO:0010629]; negative regulation of nitric-oxide synthase activity [GO:0051001]; negative regulation of pathway-restricted SMAD protein phosphorylation [GO:0060394]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of angiogenesis [GO:0045766]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation [GO:1905007]; positive regulation of gene expression [GO:0010628]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell differentiation [GO:1905065]; regulation of cell adhesion [GO:0030155]; regulation of cell population proliferation [GO:0042127]; regulation of phosphorylation [GO:0042325]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; response to corticosteroid [GO:0031960]; response to hypoxia [GO:0001666]; response to xenobiotic stimulus [GO:0009410]; smooth muscle tissue development [GO:0048745]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vascular associated smooth muscle cell development [GO:0097084]; vasculogenesis [GO:0001570]; venous blood vessel morphogenesis [GO:0048845]; ventricular trabecula myocardium morphogenesis [GO:0003222]; wound healing [GO:0042060] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S103N	TCGA-A5-A0VP	UCEC	TCGA	PREVLLVLS	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.25
p.S103N	DO42600	UCEC	ICGC	PREVLLVLS	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.25
p.S653F	TCGA-AO-A03M	BRCA	TCGA	PCSTS	DEG_SPOP_SBC_1	651:655	Mutation altering degron motif	0.7982
p.S653F	DO2216	BRCA	ICGC	PCSTS	DEG_SPOP_SBC_1	651:655	Mutation altering degron motif	0.7982
p.W91C	TCGA-ER-A19P	SKCM	TCGA	PREVLLVLS	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.3056
p.W91C	DO47623	SKCM	ICGC	PREVLLVLS	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.3056
p.P92S	TCGA-VQ-A8P8	STAD	TCGA	PREVLLVLS	DEG_APCC_DBOX_1	92:100	Mutation altering degron motif	0.5641
p.P92S	DO51764	STAD	ICGC	PREVLLVLS	DEG_APCC_DBOX_1	92:100	Mutation altering degron motif	0.5641
p.N88S	DO231590	LINC	ICGC	PREVLLVLS	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.2222
p.A84T	DO27965	ORCA	ICGC	PREVLLVLS	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.1111
p.H108Y	SIDM00594	Acute Myeloid Leukemia	GDSC	PREVLLVLS	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.1111
p.H108Y	CMK	haematopoietic and lymphoid tissue	COSMIC	PREVLLVLS	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.1111
p.H108Y	HEL	haematopoietic and lymphoid tissue	COSMIC	PREVLLVLS	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ENG

UniProt ID: P17813

Entrez ID: 2022

Protein name: Endoglin (CD antigen CD105)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ENG in