DegronMD

Uniprot ID: P17813

Source protein: Endoglin

Source gene: ENG

Class: DEG_APCC_DBOX_1

Location: 92:100

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6276

ASA_SCORE: 28.8222

COIL: 0.2674

CONS_SCORE: 0.5382

DSS_SCORE: 0.084

HELIX: 0.0103

FCONS_SCORE: 1.3529

RIG_SCORE: 0.9108

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S103N	TCGA-A5-A0VP	UCEC	TCGA	PREVLLVLS	DEG_APCC_DBOX_1	0.25
p.S103N	DO42600	UCEC	ICGC	PREVLLVLS	DEG_APCC_DBOX_1	0.25
p.W91C	TCGA-ER-A19P	SKCM	TCGA	PREVLLVLS	DEG_APCC_DBOX_1	0.3056
p.W91C	DO47623	SKCM	ICGC	PREVLLVLS	DEG_APCC_DBOX_1	0.3056
p.P92S	TCGA-VQ-A8P8	STAD	TCGA	PREVLLVLS	DEG_APCC_DBOX_1	0.5641
p.P92S	DO51764	STAD	ICGC	PREVLLVLS	DEG_APCC_DBOX_1	0.5641
p.N88S	DO231590	LINC	ICGC	PREVLLVLS	DEG_APCC_DBOX_1	0.2222
p.A84T	DO27965	ORCA	ICGC	PREVLLVLS	DEG_APCC_DBOX_1	0.1111
p.H108Y	SIDM00594	Acute Myeloid Leukemia	GDSC	PREVLLVLS	DEG_APCC_DBOX_1	0.1111
p.H108Y	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	PREVLLVLS	DEG_APCC_DBOX_1	0.1111
p.H108Y	HEL	haematopoietic_and_lymphoid_tissue	COSMIC	PREVLLVLS	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17813	Endoglin	DEG_APCC_DBOX_1	92:100	PREVLLVLS	APC,CDC20,FZR1	0.6276	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons