DegronMD

Uniprot ID: Q9P227

Source protein: Rho GTPase-activating protein 23

Source gene: ARHGAP23

Class: DEG_APCC_DBOX_1

Location: 88:96

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9913

ASA_SCORE: 74.6333

COIL: 0.7973

CONS_SCORE: 0.3166

DSS_SCORE: 0.5329

HELIX: 0.0852

FCONS_SCORE: 1.0068

RIG_SCORE: 0.7241

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R91H	TCGA-A3-3358	KIRC	TCGA	PRYRLEPMD	DEG_APCC_DBOX_1	0.7133
p.R91H	DO16144	KIRC	ICGC	PRYRLEPMD	DEG_APCC_DBOX_1	0.7133
p.E78D	TCGA-FI-A2D5	UCEC	TCGA	PRYRLEPMD	DEG_APCC_DBOX_1	0.0556
p.E78D	DO36556	READ	ICGC	PRYRLEPMD	DEG_APCC_DBOX_1	0.0556
p.E78D	DO41331	UCEC	ICGC	PRYRLEPMD	DEG_APCC_DBOX_1	0.0556
p.I98V	TCGA-FI-A2D5	UCEC	TCGA	PRYRLEPMD	DEG_APCC_DBOX_1	0.2778
p.R86H	DO233766	GACA	ICGC	PRYRLEPMD	DEG_APCC_DBOX_1	0.2778
p.R98C	DO223282	UCEC	ICGC	PRYRLEPMD	DEG_APCC_DBOX_1	0.2778
p.E79K	DO42280	UCEC	ICGC	PRYRLEPMD	DEG_APCC_DBOX_1	0.0833
p.R89W	SIDM02072	Colorectal Carcinoma	GDSC	PRYRLEPMD	DEG_APCC_DBOX_1	0.8634
p.P88R	ACH-001458	Colon/Colorectal Cancer	CCLE	PRYRLEPMD	DEG_APCC_DBOX_1	0.6401

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P227	Rho GTPase-activating protein 23	DEG_APCC_DBOX_1	88:96	PRYRLEPMD	APC,CDC20,FZR1	0.9913	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons