DegronMD

Uniprot ID: Q96LL4

Source protein: Uncharacterized protein C8orf48

Source gene: C8orf48

Class: DEG_SPOP_SBC_1

Location: 32:36

E3 ligase: SPOP

DEGRON score: 0.9889

ASA_SCORE: 76.82

COIL: 0.6778

CONS_SCORE: 0.4903

DSS_SCORE: 0.623

HELIX: 0.0798

FCONS_SCORE: 1.0447

RIG_SCORE: 0.6519

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N27T	TCGA-D1-A17Q	UCEC	TCGA	VQTSS	DEG_SPOP_SBC_1	0.1944
p.N27T	DO41903	UCEC	ICGC	VQTSS	DEG_SPOP_SBC_1	0.1944
p.S41Y	TCGA-G4-6628	COAD	TCGA	VQTSS	DEG_SPOP_SBC_1	0.1944
p.S41Y	DO10132	COAD	ICGC	VQTSS	DEG_SPOP_SBC_1	0.1944
p.N27K	TCGA-KN-8428	KICH	TCGA	VQTSS	DEG_SPOP_SBC_1	0.1944
p.N27K	DO220484	KICH	ICGC	VQTSS	DEG_SPOP_SBC_1	0.1944
p.R44W	DO1138	BRCA	ICGC	VQTSS	DEG_SPOP_SBC_1	0.1111
p.R44W	DO222706	COCA	ICGC	VQTSS	DEG_SPOP_SBC_1	0.1111
p.R44Q	DO2647	BRCA	ICGC	VQTSS	DEG_SPOP_SBC_1	0.1111
p.S39G	DO227646	COCA	ICGC	VQTSS	DEG_SPOP_SBC_1	0.25
p.S28F	DO229010	COCA	ICGC	VQTSS	DEG_SPOP_SBC_1	0.2222
p.S28F	DO229013	COCA	ICGC	VQTSS	DEG_SPOP_SBC_1	0.2222
p.S28F	DO229016	COCA	ICGC	VQTSS	DEG_SPOP_SBC_1	0.2222
p.S28F	DO229003	COCA	ICGC	VQTSS	DEG_SPOP_SBC_1	0.2222
p.S28F	DO229005	COCA	ICGC	VQTSS	DEG_SPOP_SBC_1	0.2222
p.S28F	DO234285	ESAD	ICGC	VQTSS	DEG_SPOP_SBC_1	0.2222
p.G43A	DO233865	GACA	ICGC	VQTSS	DEG_SPOP_SBC_1	0.1389
p.T29A	SIDM02069	Colorectal Carcinoma	GDSC	VQTSS	DEG_SPOP_SBC_1	0.25
p.E23G	SIDM00282	Colorectal Carcinoma	GDSC	VQTSS	DEG_SPOP_SBC_1	0.0833
p.E23G	ACH-000998	Colon/Colorectal Cancer	CCLE	VQTSS	DEG_SPOP_SBC_1	0.0833
p.T29S	SIDM00382	Glioblastoma	GDSC	VQTSS	DEG_SPOP_SBC_1	0.25
p.T29S	ACH-000609	Brain Cancer	CCLE	VQTSS	DEG_SPOP_SBC_1	0.25
p.E31K	SIDM00870	Breast Carcinoma	GDSC	VQTSS	DEG_SPOP_SBC_1	0.3056
p.E31K	ACH-000725	Breast Cancer	CCLE	VQTSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NDB9	Paralemmin-3	DEG_SPOP_SBC_1	299:303	VQTSS	SPOP	0.9963	More...
O95201	Zinc finger protein 205	DEG_SPOP_SBC_1	207:211	VQTSS	SPOP	0.9657	More...
P23381	Tryptophan--tRNA ligase, cytoplasmic	DEG_SPOP_SBC_1	90:94	VQTSS	SPOP	0.8229	More...
Q96LL4	Uncharacterized protein C8orf48	DEG_SPOP_SBC_1	32:36	VQTSS	SPOP	0.9889	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	885:889	VQTSS	SPOP	0.9482	More...
Q8WZ64	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	112:116	VQTSS	SPOP	0.9356	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons