DegronMD

Uniprot ID: A6NDB9

Source protein: Paralemmin-3

Source gene: PALM3

Class: DEG_SPOP_SBC_1

Location: 299:303

E3 ligase: SPOP

DEGRON score: 0.9963

ASA_SCORE: 87.74

COIL: 0.8656

CONS_SCORE: 0.6603

DSS_SCORE: 0.5454

HELIX: 0.0764

FCONS_SCORE: 1.1238

RIG_SCORE: 0.7464

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S303L	TCGA-DD-AAD6	LIHC	TCGA	VQTSS	DEG_SPOP_SBC_1	0.8778
p.S303L	DO52224	LIHC	ICGC	VQTSS	DEG_SPOP_SBC_1	0.8778
p.G290R	TCGA-EO-A22U	UCEC	TCGA	VQTSS	DEG_SPOP_SBC_1	0.0833
p.G290R	DO43755	UCEC	ICGC	VQTSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NDB9	Paralemmin-3	DEG_SPOP_SBC_1	299:303	VQTSS	SPOP	0.9963	More...
O95201	Zinc finger protein 205	DEG_SPOP_SBC_1	207:211	VQTSS	SPOP	0.9657	More...
P23381	Tryptophan--tRNA ligase, cytoplasmic	DEG_SPOP_SBC_1	90:94	VQTSS	SPOP	0.8229	More...
Q96LL4	Uncharacterized protein C8orf48	DEG_SPOP_SBC_1	32:36	VQTSS	SPOP	0.9889	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	885:889	VQTSS	SPOP	0.9482	More...
Q8WZ64	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	112:116	VQTSS	SPOP	0.9356	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons