DegronMD

Uniprot ID: P23381

Source protein: Tryptophan--tRNA ligase, cytoplasmic

Source gene: WARS1

Class: DEG_SPOP_SBC_1

Location: 90:94

E3 ligase: SPOP

DEGRON score: 0.8229

ASA_SCORE: 73.82

COIL: 0.711

CONS_SCORE: 0.4829

DSS_SCORE: 0.3833

HELIX: 0.1908

FCONS_SCORE: 0.9187

RIG_SCORE: 0.7934

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A95E	SIDM00112	Kidney Carcinoma	GDSC	VQTSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NDB9	Paralemmin-3	DEG_SPOP_SBC_1	299:303	VQTSS	SPOP	0.9963	More...
O95201	Zinc finger protein 205	DEG_SPOP_SBC_1	207:211	VQTSS	SPOP	0.9657	More...
P23381	Tryptophan--tRNA ligase, cytoplasmic	DEG_SPOP_SBC_1	90:94	VQTSS	SPOP	0.8229	More...
Q96LL4	Uncharacterized protein C8orf48	DEG_SPOP_SBC_1	32:36	VQTSS	SPOP	0.9889	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	885:889	VQTSS	SPOP	0.9482	More...
Q8WZ64	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	112:116	VQTSS	SPOP	0.9356	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons