DegronMD - A6NDB9(PALM3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A614D	TCGA-BS-A0UJ	UCEC	TCGA	LAETPAPE	DEG_SCF_FBW7_2	609:616	Mutation altering degron motif	0.6682
p.A614D	DO42745	UCEC	ICGC	LAETPAPE	DEG_SCF_FBW7_2	609:616	Mutation altering degron motif	0.6682
p.S303L	TCGA-DD-AAD6	LIHC	TCGA	VQTSS	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.8778
p.S303L	DO52224	LIHC	ICGC	VQTSS	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.8778
p.G290R	TCGA-EO-A22U	UCEC	TCGA	VQTSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.0833
p.G290R	DO43755	UCEC	ICGC	VQTSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.0833
p.S157C	TCGA-JW-A5VL	CESC	TCGA	LVGTPPES	DEG_SCF_FBW7_1	148:155	Mutation blocking phosphorylation signal	0.7222
p.S157C	DO49976	CESC	ICGC	LVGTPPES	DEG_SCF_FBW7_1	148:155	Mutation blocking phosphorylation signal	0.7222
p.P623S	DO10324	COAD	ICGC	LAETPAPE	DEG_SCF_FBW7_2	609:616	Mutation rewiring degron network	0.1389
p.E620K	DO222762	COCA	ICGC	LAETPAPE	DEG_SCF_FBW7_2	609:616	Mutation rewiring degron network	0.2222
p.E620K	ACH-000985	Colon/Colorectal Cancer	CCLE	LAETPAPE	DEG_SCF_FBW7_2	609:616	Mutation rewiring degron network	0.2222
p.A142V	DO233103	GACA	ICGC	LVGTPPES	DEG_SCF_FBW7_1	148:155	Mutation rewiring degron network	0.1667
p.P145S	DO233935	GACA	ICGC	LVGTPPES	DEG_SCF_FBW7_1	148:155	Mutation rewiring degron network	0.25
p.T151M	SIDM00042	Pancreatic Carcinoma	GDSC	LVGTPPES	DEG_SCF_FBW7_1	148:155	Mutation altering degron motif	0.8534
p.T151M	PL4	pancreas	COSMIC	LVGTPPES	DEG_SCF_FBW7_1	148:155	Mutation altering degron motif	0.8534
p.A605V	ACH-001991	Primary	CCLE	LAETPAPE	DEG_SCF_FBW7_2	609:616	Mutation rewiring degron network	0.2222

Kaplan plot for PALM3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PALM3

UniProt ID: A6NDB9

Entrez ID: 342979

Protein name: Paralemmin-3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PALM3 in