DegronMD

Uniprot ID: A6NDB9

Source protein: Paralemmin-3

Source gene: PALM3

Class: DEG_SCF_FBW7_1

Location: 148:155

E3 ligase: FBXW7

DEGRON score: 0.8427

ASA_SCORE: 85.8875

COIL: 0.9454

CONS_SCORE: 0.7106

DSS_SCORE: 0.7151

HELIX: 0.0151

FCONS_SCORE: 0.9336

RIG_SCORE: 0.5857

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S157C	TCGA-JW-A5VL	CESC	TCGA	LVGTPPES	DEG_SCF_FBW7_1	0.7222
p.S157C	DO49976	CESC	ICGC	LVGTPPES	DEG_SCF_FBW7_1	0.7222
p.A142V	DO233103	GACA	ICGC	LVGTPPES	DEG_SCF_FBW7_1	0.1667
p.P145S	DO233935	GACA	ICGC	LVGTPPES	DEG_SCF_FBW7_1	0.25
p.T151M	SIDM00042	Pancreatic Carcinoma	GDSC	LVGTPPES	DEG_SCF_FBW7_1	0.8534
p.T151M	PL4	pancreas	COSMIC	LVGTPPES	DEG_SCF_FBW7_1	0.8534

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NDB9	Paralemmin-3	DEG_SCF_FBW7_1	148:155	LVGTPPES	FBXW7	0.8427	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons