DegronMD

Uniprot ID: A6NDB9

Source protein: Paralemmin-3

Source gene: PALM3

Class: DEG_SCF_FBW7_2

Location: 609:616

E3 ligase: FBXW7

DEGRON score: 0.9146

ASA_SCORE: 96.6375

COIL: 0.9164

CONS_SCORE: 0.5081

DSS_SCORE: 0.7627

HELIX: 0.0461

FCONS_SCORE: 1.049

RIG_SCORE: 0.6612

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A614D	TCGA-BS-A0UJ	UCEC	TCGA	LAETPAPE	DEG_SCF_FBW7_2	0.6682
p.A614D	DO42745	UCEC	ICGC	LAETPAPE	DEG_SCF_FBW7_2	0.6682
p.E620K	DO222762	COCA	ICGC	LAETPAPE	DEG_SCF_FBW7_2	0.2222
p.E620K	ACH-000985	Colon/Colorectal Cancer	CCLE	LAETPAPE	DEG_SCF_FBW7_2	0.2222
p.A605V	ACH-001991	Primary	CCLE	LAETPAPE	DEG_SCF_FBW7_2	0.2222
p.P623S	DO10324	COAD	ICGC	LAETPAPE	DEG_SCF_FBW7_2	0.1389

Showing 1 to 6 of 6 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NDB9	Paralemmin-3	DEG_SCF_FBW7_2	609:616	LAETPAPE	FBXW7	0.9146	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons