DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VQTSS
Uniprot ID:
O95201
Source protein:
Zinc finger protein 205
Source gene:
ZNF205
Class:
DEG_SPOP_SBC_1
Location:
207:211
E3 ligase:
SPOP
DEGRON score:
0.9657
ASA_SCORE:
72.94
COIL:
0.7164
CONS_SCORE:
0.5128
DSS_SCORE:
0.3543
HELIX:
0.1318
FCONS_SCORE:
0.8441
RIG_SCORE:
0.8044
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V212M
TCGA-CG-5728
STAD
TCGA
VQTSS
DEG_SPOP_SBC_1
0.3056
p.V212M
DO38619
STAD
ICGC
VQTSS
DEG_SPOP_SBC_1
0.3056
p.Q208E
TCGA-CK-4951
COAD
TCGA
VQTSS
DEG_SPOP_SBC_1
0.5633
p.Q208E
DO10582
COAD
ICGC
VQTSS
DEG_SPOP_SBC_1
0.5633
p.S211F
TCGA-EB-A6QZ
SKCM
TCGA
VQTSS
DEG_SPOP_SBC_1
0.7982
p.S211F
DO48626
SKCM
ICGC
VQTSS
DEG_SPOP_SBC_1
0.7982
p.G199A
TCGA-EY-A1GO
UCEC
TCGA
VQTSS
DEG_SPOP_SBC_1
0.1111
p.G199A
DO41392
UCEC
ICGC
VQTSS
DEG_SPOP_SBC_1
0.1111
p.T209P
TCGA-FI-A2D5
UCEC
TCGA
VQTSS
DEG_SPOP_SBC_1
0.7031
p.T209P
DO41331
UCEC
ICGC
VQTSS
DEG_SPOP_SBC_1
0.7031
p.P220S
DO233254
GACA
ICGC
VQTSS
DEG_SPOP_SBC_1
0.0833
p.V218A
DO233634
GACA
ICGC
VQTSS
DEG_SPOP_SBC_1
0.1389
p.Q205P
DO233827
GACA
ICGC
VQTSS
DEG_SPOP_SBC_1
0.2778
p.G216W
DO50666
ORCA
ICGC
VQTSS
DEG_SPOP_SBC_1
0.1944
p.C197Y
SIDM01307
Colorectal Carcinoma
GDSC
VQTSS
DEG_SPOP_SBC_1
0.0556
p.G199R
SIDM00600
Thyroid Gland Carcinoma
GDSC
VQTSS
DEG_SPOP_SBC_1
0.1111
p.G199R
IHH-4
thyroid
COSMIC
VQTSS
DEG_SPOP_SBC_1
0.1111
p.A213E
SIDM01007
T-Lymphoblastic Leukemia
GDSC
VQTSS
DEG_SPOP_SBC_1
0.2778
p.A213E
ACH-002256
Leukemia
CCLE
VQTSS
DEG_SPOP_SBC_1
0.2778
p.A213E
KARPAS-45
haematopoietic_and_lymphoid_tissue
COSMIC
VQTSS
DEG_SPOP_SBC_1
0.2778
p.R206G
SIDM00217
Colorectal Carcinoma
GDSC
VQTSS
DEG_SPOP_SBC_1
0.3056
p.R206G
ACH-000999
Colon/Colorectal Cancer
CCLE
VQTSS
DEG_SPOP_SBC_1
0.3056
p.R206G
SNU-1040
large_intestine
COSMIC
VQTSS
DEG_SPOP_SBC_1
0.3056
p.N217Y
SIDM01526
Mesothelioma
GDSC
VQTSS
DEG_SPOP_SBC_1
0.1667
Drug responses associated with ZNF205 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VQTSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NDB9
Paralemmin-3
DEG_SPOP_SBC_1
299:303
VQTSS
SPOP
0.9963
More...
O95201
Zinc finger protein 205
DEG_SPOP_SBC_1
207:211
VQTSS
SPOP
0.9657
More...
P23381
Tryptophan--tRNA ligase, cytoplasmic
DEG_SPOP_SBC_1
90:94
VQTSS
SPOP
0.8229
More...
Q96LL4
Uncharacterized protein C8orf48
DEG_SPOP_SBC_1
32:36
VQTSS
SPOP
0.9889
More...
Q99700
Ataxin-2
DEG_SPOP_SBC_1
885:889
VQTSS
SPOP
0.9482
More...
Q8WZ64
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
DEG_SPOP_SBC_1
112:116
VQTSS
SPOP
0.9356
More...