DegronMD

Uniprot ID: O95201

Source protein: Zinc finger protein 205

Source gene: ZNF205

Class: DEG_SPOP_SBC_1

Location: 207:211

E3 ligase: SPOP

DEGRON score: 0.9657

ASA_SCORE: 72.94

COIL: 0.7164

CONS_SCORE: 0.5128

DSS_SCORE: 0.3543

HELIX: 0.1318

FCONS_SCORE: 0.8441

RIG_SCORE: 0.8044

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S211F	TCGA-EB-A6QZ	SKCM	TCGA	VQTSS	DEG_SPOP_SBC_1	0.7982
p.S211F	DO48626	SKCM	ICGC	VQTSS	DEG_SPOP_SBC_1	0.7982
p.T209P	TCGA-FI-A2D5	UCEC	TCGA	VQTSS	DEG_SPOP_SBC_1	0.7031
p.T209P	DO41331	UCEC	ICGC	VQTSS	DEG_SPOP_SBC_1	0.7031
p.Q208E	TCGA-CK-4951	COAD	TCGA	VQTSS	DEG_SPOP_SBC_1	0.5633
p.Q208E	DO10582	COAD	ICGC	VQTSS	DEG_SPOP_SBC_1	0.5633
p.V212M	TCGA-CG-5728	STAD	TCGA	VQTSS	DEG_SPOP_SBC_1	0.3056
p.V212M	DO38619	STAD	ICGC	VQTSS	DEG_SPOP_SBC_1	0.3056
p.R206G	SIDM00217	Colorectal Carcinoma	GDSC	VQTSS	DEG_SPOP_SBC_1	0.3056
p.R206G	ACH-000999	Colon/Colorectal Cancer	CCLE	VQTSS	DEG_SPOP_SBC_1	0.3056
p.R206G	SNU-1040	large_intestine	COSMIC	VQTSS	DEG_SPOP_SBC_1	0.3056
p.Q205P	DO233827	GACA	ICGC	VQTSS	DEG_SPOP_SBC_1	0.2778
p.A213E	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VQTSS	DEG_SPOP_SBC_1	0.2778
p.A213E	ACH-002256	Leukemia	CCLE	VQTSS	DEG_SPOP_SBC_1	0.2778
p.A213E	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VQTSS	DEG_SPOP_SBC_1	0.2778
p.G216W	DO50666	ORCA	ICGC	VQTSS	DEG_SPOP_SBC_1	0.1944
p.N217Y	SIDM01526	Mesothelioma	GDSC	VQTSS	DEG_SPOP_SBC_1	0.1667
p.V218A	DO233634	GACA	ICGC	VQTSS	DEG_SPOP_SBC_1	0.1389
p.G199A	TCGA-EY-A1GO	UCEC	TCGA	VQTSS	DEG_SPOP_SBC_1	0.1111
p.G199A	DO41392	UCEC	ICGC	VQTSS	DEG_SPOP_SBC_1	0.1111
p.G199R	SIDM00600	Thyroid Gland Carcinoma	GDSC	VQTSS	DEG_SPOP_SBC_1	0.1111
p.G199R	IHH-4	thyroid	COSMIC	VQTSS	DEG_SPOP_SBC_1	0.1111
p.P220S	DO233254	GACA	ICGC	VQTSS	DEG_SPOP_SBC_1	0.0833
p.C197Y	SIDM01307	Colorectal Carcinoma	GDSC	VQTSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 24 of 24 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ64	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	112:116	VQTSS	SPOP	0.9356	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	885:889	VQTSS	SPOP	0.9482	More...
A6NDB9	Paralemmin-3	DEG_SPOP_SBC_1	299:303	VQTSS	SPOP	0.9963	More...
P23381	Tryptophan--tRNA ligase, cytoplasmic	DEG_SPOP_SBC_1	90:94	VQTSS	SPOP	0.8229	More...
Q96LL4	Uncharacterized protein C8orf48	DEG_SPOP_SBC_1	32:36	VQTSS	SPOP	0.9889	More...
O95201	Zinc finger protein 205	DEG_SPOP_SBC_1	207:211	VQTSS	SPOP	0.9657	More...

Showing 1 to 6 of 6 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons