DegronMD

Uniprot ID: Q99700

Source protein: Ataxin-2

Source gene: ATXN2

Class: DEG_SCF_FBW7_1

Location: 954:959

E3 ligase: FBXW7

DEGRON score: 0.5736

ASA_SCORE: 91.0333

COIL: 0.917

CONS_SCORE: 0.3313

DSS_SCORE: 0.4379

HELIX: 0.018

FCONS_SCORE: 1.1914

RIG_SCORE: 0.7001

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P954S	SIDM01245	T-Lymphoblastic Leukemia	GDSC	PTPVYT	DEG_SCF_FBW7_1	0.6752
p.P954S	SIDM00920	Breast Carcinoma	GDSC	PTPVYT	DEG_SCF_FBW7_1	0.6752
p.P954S	SIDM00991	T-Lymphoblastic Leukemia	GDSC	PTPVYT	DEG_SCF_FBW7_1	0.6752
p.Y958H	TCGA-DI-A1BU	UCEC	TCGA	PTPVYT	DEG_SCF_FBW7_1	0.6118
p.H951Y	TCGA-69-7979	LUAD	TCGA	PTPVYT	DEG_SCF_FBW7_1	0.25
p.V962A	TCGA-EO-A22R	UCEC	TCGA	PTPVYT	DEG_SCF_FBW7_1	0.25
p.V962A	DO50327	ESAD	ICGC	PTPVYT	DEG_SCF_FBW7_1	0.25
p.H966Y	DO14526	HNSC	ICGC	PTPVYT	DEG_SCF_FBW7_1	0.1389
p.H966Y	DO37707	SKCM	ICGC	PTPVYT	DEG_SCF_FBW7_1	0.1389
p.H966Q	DO16248	KIRC	ICGC	PTPVYT	DEG_SCF_FBW7_1	0.1389
p.N947K	DO229031	LICA	ICGC	PTPVYT	DEG_SCF_FBW7_1	0.1389
p.T966M	GP5d	large_intestine	COSMIC	PTPVYT	DEG_SCF_FBW7_1	0.1389
p.S946C	DO49976	CESC	ICGC	PTPVYT	DEG_SCF_FBW7_1	0.1111
p.M968I	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PTPVYT	DEG_SCF_FBW7_1	0.0833
p.M968I	NCI-H1155	lung	COSMIC	PTPVYT	DEG_SCF_FBW7_1	0.0833
p.V968L	H513	pleura	COSMIC	PTPVYT	DEG_SCF_FBW7_1	0.0833
p.P944S	DO52073	HNSC	ICGC	PTPVYT	DEG_SCF_FBW7_1	0.0556
p.H969Q	DO23996	LUAD	ICGC	PTPVYT	DEG_SCF_FBW7_1	0.0556

Showing 1 to 18 of 18 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99700	Ataxin-2	DEG_SCF_FBW7_1	954:959	PTPVYT	FBXW7	0.5736	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons