DegronMD

Uniprot ID: Q99700

Source protein: Ataxin-2

Source gene: ATXN2

Class: DEG_SCF_FBW7_2

Location: 740:745

E3 ligase: FBXW7

DEGRON score: 0.6704

ASA_SCORE: 86.6

COIL: 0.8737

CONS_SCORE: 0.2461

DSS_SCORE: 0.748

HELIX: 0.1068

FCONS_SCORE: 0.8533

RIG_SCORE: 0.5933

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A739D	TCGA-AX-A1CE	UCEC	TCGA	VTPSSE	DEG_SCF_FBW7_2	0.3056
p.T730M	TCGA-BG-A0M7	UCEC	TCGA	VTPSSE	DEG_SCF_FBW7_2	0.5
p.A732D	TCGA-CR-6491	HNSC	TCGA	VTPSSE	DEG_SCF_FBW7_2	0.1111
p.M740V	DO8224	COAD	ICGC	VTPSSE	DEG_SCF_FBW7_2	0.7208
p.S751T	DO234206	ESAD	ICGC	VTPSSE	DEG_SCF_FBW7_2	0.1667
p.K736T	DO40884	UCEC	ICGC	VTPSSE	DEG_SCF_FBW7_2	0.6667
p.R755M	SIDM00214	Colorectal Carcinoma	GDSC	VTPSSE	DEG_SCF_FBW7_2	0.0556
p.R755M	SNU-407	large_intestine	COSMIC	VTPSSE	DEG_SCF_FBW7_2	0.0556
p.V740F	SIDM00233	T-Lymphoblastic Leukemia	GDSC	VTPSSE	DEG_SCF_FBW7_2	0.7068
p.V740F	ATN-1	haematopoietic_and_lymphoid_tissue	COSMIC	VTPSSE	DEG_SCF_FBW7_2	0.7068
p.A745T	SNU-1040	large_intestine	COSMIC	VTPSSE	DEG_SCF_FBW7_2	0.7139
p.M738I	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	VTPSSE	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99700	Ataxin-2	DEG_SCF_FBW7_2	740:745	VTPSSE	FBXW7	0.6704	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons