DegronMD - O94762(RECQL5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R17Q	TCGA-BG-A221	UCEC	TCGA	VRSTLKKVF	DEG_APCC_DBOX_1	16:24	Mutation altering degron motif	0.7329
p.R17Q	DO233747	GACA	ICGC	VRSTLKKVF	DEG_APCC_DBOX_1	16:24	Mutation altering degron motif	0.7329
p.R17Q	DO42384	UCEC	ICGC	VRSTLKKVF	DEG_APCC_DBOX_1	16:24	Mutation altering degron motif	0.7329
p.L741F	TCGA-DI-A1BU	UCEC	TCGA	AKSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1944
p.L741F	DO42023	UCEC	ICGC	AKSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1944
p.P728L	TCGA-EE-A2MR	SKCM	TCGA	AKSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.2222
p.P728L	DO37819	SKCM	ICGC	AKSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.2222
p.H722Y	TCGA-NH-A6GB	COAD	TCGA	AKSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.0556
p.H722Y	DO50092	COAD	ICGC	AKSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.0556
p.P12L	TCGA-R6-A6L6	ESCA	TCGA	VRSTLKKVF	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.2222
p.R14W	TCGA-WS-AB45	COAD	TCGA	VRSTLKKVF	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.2778
p.R14W	DO51734	COAD	ICGC	VRSTLKKVF	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.2778
p.G724E	TCGA-XV-AAZW	SKCM	TCGA	AKSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1111
p.G724E	DO219495	SKCM	ICGC	AKSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1111
p.R745Q	DO224798	BRCA	ICGC	AKSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.0833
p.R745Q	DO23322	LINC	ICGC	AKSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.0833
p.A732E	DO228939	LICA	ICGC	AKSSS	DEG_SPOP_SBC_1	732:736	Mutation altering degron motif	0.7701
p.D11E	DO228986	LICA	ICGC	VRSTLKKVF	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.1944
p.E729K	DO229544	UTCA	ICGC	AKSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.25
p.S734R	SIDM00545	Melanoma	GDSC	AKSSS	DEG_SPOP_SBC_1	732:736	Mutation altering degron motif	0.7427
p.S734R	ACH-000987	Skin Cancer	CCLE	AKSSS	DEG_SPOP_SBC_1	732:736	Mutation altering degron motif	0.7427
p.G725W	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	AKSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1389
p.G725W	ACH-000945	Lung Cancer	CCLE	AKSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1389
p.G725W	NCI-H650	lung	COSMIC	AKSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1389
p.A729V	LIM1215	large intestine	COSMIC	AKSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.25

Kaplan plot for RECQL5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RECQL5

UniProt ID: O94762

Entrez ID: 9400

Protein name: ATP-dependent DNA helicase Q5 (EC 3.6.4.12) (DNA helicase, RecQ-like type 5) (RecQ5) (RecQ protein-like 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RECQL5 in