DegronMD

Uniprot ID: O94762

Source protein: ATP-dependent DNA helicase Q5

Source gene: RECQL5

Class: DEG_APCC_DBOX_1

Location: 16:24

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9447

ASA_SCORE: 50.0444

COIL: 0.0674

CONS_SCORE: 0.5429

DSS_SCORE: 0.2729

HELIX: 0.931

FCONS_SCORE: 1.1801

RIG_SCORE: 0.8017

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R17Q	TCGA-BG-A221	UCEC	TCGA	VRSTLKKVF	DEG_APCC_DBOX_1	0.7329
p.R17Q	DO233747	GACA	ICGC	VRSTLKKVF	DEG_APCC_DBOX_1	0.7329
p.R17Q	DO42384	UCEC	ICGC	VRSTLKKVF	DEG_APCC_DBOX_1	0.7329
p.P12L	TCGA-R6-A6L6	ESCA	TCGA	VRSTLKKVF	DEG_APCC_DBOX_1	0.2222
p.R14W	TCGA-WS-AB45	COAD	TCGA	VRSTLKKVF	DEG_APCC_DBOX_1	0.2778
p.R14W	DO51734	COAD	ICGC	VRSTLKKVF	DEG_APCC_DBOX_1	0.2778
p.D11E	DO228986	LICA	ICGC	VRSTLKKVF	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94762	ATP-dependent DNA helicase Q5	DEG_APCC_DBOX_1	16:24	VRSTLKKVF	APC,CDC20,FZR1	0.9447	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons