DegronMD - Q8NEY1(NAV1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P676A	TCGA-17-Z033	LUAD	TCGA	AKSSS	DEG_SPOP_SBC_1	677:681	Mutation rewiring degron network	0.3056
p.Q669K	TCGA-22-4609	LUSC	TCGA	AKSSS	DEG_SPOP_SBC_1	677:681	Mutation rewiring degron network	0.1111
p.Q669K	DO26838	LUSC	ICGC	AKSSS	DEG_SPOP_SBC_1	677:681	Mutation rewiring degron network	0.1111
p.R671H	TCGA-2W-A8YY	CESC	TCGA	AKSSS	DEG_SPOP_SBC_1	677:681	Mutation rewiring degron network	0.1667
p.R671H	DO223732	CESC	ICGC	AKSSS	DEG_SPOP_SBC_1	677:681	Mutation rewiring degron network	0.1667
p.V455M	TCGA-78-7159	LUAD	TCGA	LPSTPTAS	DEG_SCF_FBW7_1	441:448	Mutation rewiring degron network	0.1389
p.R688Q	TCGA-A5-A0GI	UCEC	TCGA	AKSSS	DEG_SPOP_SBC_1	677:681	Mutation rewiring degron network	0.1389
p.R688Q	TCGA-A5-A0GI	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.1944
p.M892I	TCGA-AA-A010	COAD	TCGA	SSTPVPTP	DEG_COP1_1	900:907	Mutation rewiring degron network	0.1111
p.M892I	TCGA-AA-A010	COAD	TCGA	PSSTPVPT	DEG_SCF_FBW7_1	899:906	Mutation rewiring degron network	0.1389
p.L894I	TCGA-AX-A1CE	UCEC	TCGA	SSTPVPTP	DEG_COP1_1	900:907	Mutation rewiring degron network	0.1667
p.L894I	TCGA-AX-A1CE	UCEC	TCGA	PSSTPVPT	DEG_SCF_FBW7_1	899:906	Mutation rewiring degron network	0.1944
p.L894I	DO42280	UCEC	ICGC	SSTPVPTP	DEG_COP1_1	900:907	Mutation rewiring degron network	0.1667
p.L894I	DO42280	UCEC	ICGC	PSSTPVPT	DEG_SCF_FBW7_1	899:906	Mutation rewiring degron network	0.1944
p.R457C	TCGA-AZ-4315	COAD	TCGA	LPSTPTAS	DEG_SCF_FBW7_1	441:448	Mutation rewiring degron network	0.0833
p.K170N	TCGA-B6-A0I8	BRCA	TCGA	GPYAEVKPL	DEG_SIAH_1	177:185	Mutation substituting flanking lysine	0.25
p.K170N	DO2149	BRCA	ICGC	GPYAEVKPL	DEG_SIAH_1	177:185	Mutation substituting flanking lysine	0.25
p.P184L	TCGA-BR-8487	STAD	TCGA	GPYAEVKPL	DEG_SIAH_1	177:185	Mutation altering degron motif	0.7582
p.P184L	DO47867	STAD	ICGC	GPYAEVKPL	DEG_SIAH_1	177:185	Mutation altering degron motif	0.7582
p.S900N	TCGA-CC-A7IL	LIHC	TCGA	SSTPVPTP	DEG_COP1_1	900:907	Mutation altering degron motif	0.7069
p.S900N	TCGA-CC-A7IL	LIHC	TCGA	PSSTPVPT	DEG_SCF_FBW7_1	899:906	Mutation altering degron motif	0.5958
p.S900N	DO52185	LIHC	ICGC	SSTPVPTP	DEG_COP1_1	900:907	Mutation altering degron motif	0.7069
p.S900N	DO52185	LIHC	ICGC	PSSTPVPT	DEG_SCF_FBW7_1	899:906	Mutation altering degron motif	0.5958
p.S452L	TCGA-CU-A3KJ	BLCA	TCGA	LPSTPTAS	DEG_SCF_FBW7_1	441:448	Mutation blocking phosphorylation signal	0.6667
p.T915I	TCGA-D1-A15X	UCEC	TCGA	SSTPVPTP	DEG_COP1_1	900:907	Mutation rewiring degron network	0.1111
p.T915I	TCGA-D1-A15X	UCEC	TCGA	PSSTPVPT	DEG_SCF_FBW7_1	899:906	Mutation rewiring degron network	0.0833
p.T915I	DO43274	UCEC	ICGC	SSTPVPTP	DEG_COP1_1	900:907	Mutation rewiring degron network	0.1111
p.T915I	DO43274	UCEC	ICGC	PSSTPVPT	DEG_SCF_FBW7_1	899:906	Mutation rewiring degron network	0.0833
p.P171L	TCGA-L5-A8NR	ESCA	TCGA	GPYAEVKPL	DEG_SIAH_1	177:185	Mutation rewiring degron network	0.1667
p.P445S	TCGA-YC-A89H	BLCA	TCGA	LPSTPTAS	DEG_SCF_FBW7_1	441:448	Mutation altering degron motif	0.6752
p.S214F	TCGA-ZF-A9R7	BLCA	TCGA	SSGPVPSA	DEG_COP1_1	213:220	Mutation altering degron motif	0.7982
p.S214F	DO219064	BLCA	ICGC	SSGPVPSA	DEG_COP1_1	213:220	Mutation altering degron motif	0.7982
p.S203L	DO51915	BLCA	ICGC	SSGPVPSA	DEG_COP1_1	213:220	Mutation rewiring degron network	0.0556
p.S203L	DO1263	BRCA	ICGC	SSGPVPSA	DEG_COP1_1	213:220	Mutation rewiring degron network	0.0556
p.E684K	DO219589	BRCA	ICGC	AKSSS	DEG_SPOP_SBC_1	677:681	Mutation rewiring degron network	0.25
p.E684K	DO219589	BRCA	ICGC	PVSSS	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.0833
p.M892V	DO234316	ESAD	ICGC	SSTPVPTP	DEG_COP1_1	900:907	Mutation rewiring degron network	0.1111
p.M892V	DO234316	ESAD	ICGC	PSSTPVPT	DEG_SCF_FBW7_1	899:906	Mutation rewiring degron network	0.1389
p.M682I	DO233207	GACA	ICGC	AKSSS	DEG_SPOP_SBC_1	677:681	Mutation rewiring degron network	0.3056
p.R173Q	DO233210	GACA	ICGC	GPYAEVKPL	DEG_SIAH_1	177:185	Mutation rewiring degron network	0.2222
p.T902A	DO228359	LICA	ICGC	SSTPVPTP	DEG_COP1_1	900:907	Mutation altering degron motif	0.6028
p.T902A	DO228359	LICA	ICGC	PSSTPVPT	DEG_SCF_FBW7_1	899:906	Mutation altering degron motif	0.7139
p.S213I	DO229027	LICA	ICGC	SSGPVPSA	DEG_COP1_1	213:220	Mutation altering degron motif	0.7341
p.S896I	DO229027	LICA	ICGC	SSTPVPTP	DEG_COP1_1	900:907	Mutation rewiring degron network	0.2222
p.S896I	DO229027	LICA	ICGC	PSSTPVPT	DEG_SCF_FBW7_1	899:906	Mutation rewiring degron network	0.25
p.V217F	DO229035	LICA	ICGC	SSGPVPSA	DEG_COP1_1	213:220	Mutation altering degron motif	0.7068
p.E1254K	DO24237	LUAD	ICGC	IATPDSS	DEG_SCF_FBW7_1	1243:1249	Mutation rewiring degron network	0.1944
p.S689Y	DO218946	LUAD	ICGC	AKSSS	DEG_SPOP_SBC_1	677:681	Mutation rewiring degron network	0.1111
p.S689Y	DO218946	LUAD	ICGC	PVSSS	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.2222
p.H892Y	DO219131	LUSC	ICGC	SSTPVPTP	DEG_COP1_1	900:907	Mutation rewiring degron network	0.1111
p.H892Y	DO219131	LUSC	ICGC	PSSTPVPT	DEG_SCF_FBW7_1	899:906	Mutation rewiring degron network	0.1389
p.R692H	DO52134	PAEN	ICGC	PVSSS	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.3056
p.S695I	DO232224	PBCA	ICGC	PVSSS	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.7341
p.P1258S	DO229502	SKCA	ICGC	IATPDSS	DEG_SCF_FBW7_1	1243:1249	Mutation rewiring degron network	0.0833
p.P178S	DO38404	STAD	ICGC	GPYAEVKPL	DEG_SIAH_1	177:185	Mutation altering degron motif	0.6752
p.S1235F	SIDM00672	Hepatocellular Carcinoma	GDSC	IATPDSS	DEG_SCF_FBW7_1	1243:1249	Mutation rewiring degron network	0.1111
p.S1235Y	SIDM00185	Melanoma	GDSC	IATPDSS	DEG_SCF_FBW7_1	1243:1249	Mutation rewiring degron network	0.1111
p.S1235Y	SIDM01650	Non-Cancerous	GDSC	IATPDSS	DEG_SCF_FBW7_1	1243:1249	Mutation rewiring degron network	0.1111
p.V684M	SIDM01164	Glioma	GDSC	AKSSS	DEG_SPOP_SBC_1	677:681	Mutation rewiring degron network	0.25
p.V684M	SIDM01164	Glioma	GDSC	PVSSS	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.0833
p.V684M	SW1783	central nervous system	COSMIC	AKSSS	DEG_SPOP_SBC_1	677:681	Mutation rewiring degron network	0.25
p.V684M	SW1783	central nervous system	COSMIC	PVSSS	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.0833
p.S440C	SIDM00854	Burkitt's Lymphoma	GDSC	LPSTPTAS	DEG_SCF_FBW7_1	441:448	Mutation blocking phosphorylation signal	0.75
p.S440C	GA-10	haematopoietic and lymphoid tissue	COSMIC	LPSTPTAS	DEG_SCF_FBW7_1	441:448	Mutation blocking phosphorylation signal	0.75
p.V904I	SIDM00510	Small Cell Lung Carcinoma	GDSC	SSTPVPTP	DEG_COP1_1	900:907	Mutation altering degron motif	0.7076
p.V904I	SIDM00510	Small Cell Lung Carcinoma	GDSC	PSSTPVPT	DEG_SCF_FBW7_1	899:906	Mutation altering degron motif	0.5965
p.V904I	COR-L303	lung	COSMIC	SSTPVPTP	DEG_COP1_1	900:907	Mutation altering degron motif	0.7076
p.V904I	COR-L303	lung	COSMIC	PSSTPVPT	DEG_SCF_FBW7_1	899:906	Mutation altering degron motif	0.5965
p.A180V	SIDM00837	Colorectal Carcinoma	GDSC	GPYAEVKPL	DEG_SIAH_1	177:185	Mutation altering degron motif	0.6936
p.A180V	SW48	large intestine	COSMIC	GPYAEVKPL	DEG_SIAH_1	177:185	Mutation altering degron motif	0.6936
p.G690A	SIDM01127	Non-Small Cell Lung Carcinoma	GDSC	AKSSS	DEG_SPOP_SBC_1	677:681	Mutation rewiring degron network	0.0833
p.G690A	SIDM01127	Non-Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.25
p.G690A	NCI-H596	lung	COSMIC	AKSSS	DEG_SPOP_SBC_1	677:681	Mutation rewiring degron network	0.0833
p.G690A	NCI-H596	lung	COSMIC	PVSSS	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.25
p.E195K	SIDM01066	Melanoma	GDSC	GPYAEVKPL	DEG_SIAH_1	177:185	Mutation rewiring degron network	0.0556
p.E195K	IGR-37	skin	COSMIC	GPYAEVKPL	DEG_SIAH_1	177:185	Mutation rewiring degron network	0.0556
p.P184S	SIDM00438	B-Lymphoblastic Leukemia	GDSC	GPYAEVKPL	DEG_SIAH_1	177:185	Mutation altering degron motif	0.6752
p.P184S	MN-60	haematopoietic and lymphoid tissue	COSMIC	GPYAEVKPL	DEG_SIAH_1	177:185	Mutation altering degron motif	0.6752
p.V193M	SIDM01617	Endometrial Carcinoma	GDSC	GPYAEVKPL	DEG_SIAH_1	177:185	Mutation rewiring degron network	0.1111
p.S896T	SIDM01433	Kidney Carcinoma	GDSC	SSTPVPTP	DEG_COP1_1	900:907	Mutation rewiring degron network	0.2222
p.S896T	SIDM01433	Kidney Carcinoma	GDSC	PSSTPVPT	DEG_SCF_FBW7_1	899:906	Mutation rewiring degron network	0.25
p.P176L	ACH-000098	Brain Cancer	CCLE	GPYAEVKPL	DEG_SIAH_1	177:185	Mutation rewiring degron network	0.3056
p.P176L	GAMG	central nervous system	COSMIC	GPYAEVKPL	DEG_SIAH_1	177:185	Mutation rewiring degron network	0.3056
p.G703A	ACH-000628	Lung Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.1667
p.G703A	NCI-H596	lung	COSMIC	PVSSS	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.1667
p.E208K	ACH-000650	Skin Cancer	CCLE	SSGPVPSA	DEG_COP1_1	213:220	Mutation rewiring degron network	0.1944
p.E208K	IGR-37	skin	COSMIC	SSGPVPSA	DEG_COP1_1	213:220	Mutation rewiring degron network	0.1944
p.V697M	ACH-000883	Brain Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.7208
p.V697M	SW1783	central nervous system	COSMIC	PVSSS	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.7208
p.A193V	ACH-000958	Colon/Colorectal Cancer	CCLE	GPYAEVKPL	DEG_SIAH_1	177:185	Mutation rewiring degron network	0.1111
p.A193V	SW48	large intestine	COSMIC	GPYAEVKPL	DEG_SIAH_1	177:185	Mutation rewiring degron network	0.1111
p.V206M	ACH-000994	Endometrial/Uterine Cancer	CCLE	SSGPVPSA	DEG_COP1_1	213:220	Mutation rewiring degron network	0.1389
p.L686R	ACH-001518	Endometrial/Uterine Cancer	CCLE	AKSSS	DEG_SPOP_SBC_1	677:681	Mutation rewiring degron network	0.1944
p.L686R	ACH-001518	Endometrial/Uterine Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.1389
p.V917I	ACH-002095	Lung Cancer	CCLE	SSTPVPTP	DEG_COP1_1	900:907	Mutation rewiring degron network	0.0556
p.V917I	COR-L303	lung	COSMIC	SSTPVPTP	DEG_COP1_1	900:907	Mutation rewiring degron network	0.0556
p.S453C	GA-10	haematopoietic and lymphoid tissue	COSMIC	LPSTPTAS	DEG_SCF_FBW7_1	441:448	Mutation blocking phosphorylation signal	0.6389
p.A170T	NU-DUL-1	haematopoietic and lymphoid tissue	COSMIC	GPYAEVKPL	DEG_SIAH_1	177:185	Mutation substituting flanking lysine	0.25
p.A226T	GR-ST	haematopoietic and lymphoid tissue	COSMIC	SSGPVPSA	DEG_COP1_1	213:220	Mutation rewiring degron network	0.1667
p.L446I	SW900	lung	COSMIC	LPSTPTAS	DEG_SCF_FBW7_1	441:448	Mutation altering degron motif	0.7174
p.R693Q	PC-14	lung	COSMIC	PVSSS	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.7329

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NAV1

UniProt ID: Q8NEY1

Entrez ID: 89796

Protein name: Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NAV1 in