DegronMD

Uniprot ID: Q8NEY1

Source protein: Neuron navigator 1

Source gene: NAV1

Class: DEG_SIAH_1

Location: 177:185

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9032

ASA_SCORE: 88.1111

COIL: 0.7847

CONS_SCORE: 0.4635

DSS_SCORE: 0.5655

HELIX: 0.0797

FCONS_SCORE: 0.9807

RIG_SCORE: 0.6799

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K170N	TCGA-B6-A0I8	BRCA	TCGA	GPYAEVKPL	DEG_SIAH_1	0.25
p.K170N	DO2149	BRCA	ICGC	GPYAEVKPL	DEG_SIAH_1	0.25
p.P184L	TCGA-BR-8487	STAD	TCGA	GPYAEVKPL	DEG_SIAH_1	0.7582
p.P184L	DO47867	STAD	ICGC	GPYAEVKPL	DEG_SIAH_1	0.7582
p.P171L	TCGA-L5-A8NR	ESCA	TCGA	GPYAEVKPL	DEG_SIAH_1	0.1667
p.R173Q	DO233210	GACA	ICGC	GPYAEVKPL	DEG_SIAH_1	0.2222
p.P178S	DO38404	STAD	ICGC	GPYAEVKPL	DEG_SIAH_1	0.6752
p.A180V	SIDM00837	Colorectal Carcinoma	GDSC	GPYAEVKPL	DEG_SIAH_1	0.6936
p.A180V	SW48	large_intestine	COSMIC	GPYAEVKPL	DEG_SIAH_1	0.6936
p.E195K	SIDM01066	Melanoma	GDSC	GPYAEVKPL	DEG_SIAH_1	0.0556
p.E195K	IGR-37	skin	COSMIC	GPYAEVKPL	DEG_SIAH_1	0.0556
p.P184S	SIDM00438	B-Lymphoblastic Leukemia	GDSC	GPYAEVKPL	DEG_SIAH_1	0.6752
p.P184S	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	GPYAEVKPL	DEG_SIAH_1	0.6752
p.V193M	SIDM01617	Endometrial Carcinoma	GDSC	GPYAEVKPL	DEG_SIAH_1	0.1111
p.P176L	ACH-000098	Brain Cancer	CCLE	GPYAEVKPL	DEG_SIAH_1	0.3056
p.P176L	GAMG	central_nervous_system	COSMIC	GPYAEVKPL	DEG_SIAH_1	0.3056
p.A193V	ACH-000958	Colon/Colorectal Cancer	CCLE	GPYAEVKPL	DEG_SIAH_1	0.1111
p.A193V	SW48	large_intestine	COSMIC	GPYAEVKPL	DEG_SIAH_1	0.1111
p.A170T	NU-DUL-1	haematopoietic_and_lymphoid_tissue	COSMIC	GPYAEVKPL	DEG_SIAH_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEY1	Neuron navigator 1	DEG_SIAH_1	177:185	GPYAEVKPL	SIAH1,SIAH2,SIAH3	0.9032	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons