DegronMD

Uniprot ID: Q8NEY1

Source protein: Neuron navigator 1

Source gene: NAV1

Class: DEG_COP1_1

Location: 213:220

E3 ligase: COP1

DEGRON score: 0.9901

ASA_SCORE: 81.0625

COIL: 0.908

CONS_SCORE: 0.4182

DSS_SCORE: 0.6145

HELIX: 0.0463

FCONS_SCORE: 0.8975

RIG_SCORE: 0.5712

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S214F	TCGA-ZF-A9R7	BLCA	TCGA	SSGPVPSA	DEG_COP1_1	0.7982
p.S214F	DO219064	BLCA	ICGC	SSGPVPSA	DEG_COP1_1	0.7982
p.S203L	DO51915	BLCA	ICGC	SSGPVPSA	DEG_COP1_1	0.0556
p.S203L	DO1263	BRCA	ICGC	SSGPVPSA	DEG_COP1_1	0.0556
p.S213I	DO229027	LICA	ICGC	SSGPVPSA	DEG_COP1_1	0.7341
p.V217F	DO229035	LICA	ICGC	SSGPVPSA	DEG_COP1_1	0.7068
p.E208K	ACH-000650	Skin Cancer	CCLE	SSGPVPSA	DEG_COP1_1	0.1944
p.E208K	IGR-37	skin	COSMIC	SSGPVPSA	DEG_COP1_1	0.1944
p.V206M	ACH-000994	Endometrial/Uterine Cancer	CCLE	SSGPVPSA	DEG_COP1_1	0.1389
p.A226T	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	SSGPVPSA	DEG_COP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEY1	Neuron navigator 1	DEG_COP1_1	213:220	SSGPVPSA	COP1	0.9901	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons