DegronMD

Uniprot ID: Q8NEY1

Source protein: Neuron navigator 1

Source gene: NAV1

Class: DEG_SCF_FBW7_1

Location: 899:906

E3 ligase: FBXW7

DEGRON score: 0.969

ASA_SCORE: 88.7375

COIL: 0.9711

CONS_SCORE: 0.3525

DSS_SCORE: 0.6865

HELIX: 0.0139

FCONS_SCORE: 0.9155

RIG_SCORE: 0.5309

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M892I	TCGA-AA-A010	COAD	TCGA	PSSTPVPT	DEG_SCF_FBW7_1	0.1389
p.L894I	TCGA-AX-A1CE	UCEC	TCGA	PSSTPVPT	DEG_SCF_FBW7_1	0.1944
p.L894I	DO42280	UCEC	ICGC	PSSTPVPT	DEG_SCF_FBW7_1	0.1944
p.S900N	TCGA-CC-A7IL	LIHC	TCGA	PSSTPVPT	DEG_SCF_FBW7_1	0.5958
p.S900N	DO52185	LIHC	ICGC	PSSTPVPT	DEG_SCF_FBW7_1	0.5958
p.T915I	TCGA-D1-A15X	UCEC	TCGA	PSSTPVPT	DEG_SCF_FBW7_1	0.0833
p.T915I	DO43274	UCEC	ICGC	PSSTPVPT	DEG_SCF_FBW7_1	0.0833
p.M892V	DO234316	ESAD	ICGC	PSSTPVPT	DEG_SCF_FBW7_1	0.1389
p.T902A	DO228359	LICA	ICGC	PSSTPVPT	DEG_SCF_FBW7_1	0.7139
p.S896I	DO229027	LICA	ICGC	PSSTPVPT	DEG_SCF_FBW7_1	0.25
p.H892Y	DO219131	LUSC	ICGC	PSSTPVPT	DEG_SCF_FBW7_1	0.1389
p.V904I	SIDM00510	Small Cell Lung Carcinoma	GDSC	PSSTPVPT	DEG_SCF_FBW7_1	0.5965
p.V904I	COR-L303	lung	COSMIC	PSSTPVPT	DEG_SCF_FBW7_1	0.5965
p.S896T	SIDM01433	Kidney Carcinoma	GDSC	PSSTPVPT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEY1	Neuron navigator 1	DEG_SCF_FBW7_1	899:906	PSSTPVPT	FBXW7	0.969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons