DegronMD

Uniprot ID: Q8NEY1

Source protein: Neuron navigator 1

Source gene: NAV1

Class: DEG_SCF_FBW7_1

Location: 1243:1249

E3 ligase: FBXW7

DEGRON score: 0.9984

ASA_SCORE: 83.8143

COIL: 0.845

CONS_SCORE: 0.4598

DSS_SCORE: 0.5872

HELIX: 0.1397

FCONS_SCORE: 1.0356

RIG_SCORE: 0.6297

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1254K	DO24237	LUAD	ICGC	IATPDSS	DEG_SCF_FBW7_1	0.1944
p.P1258S	DO229502	SKCA	ICGC	IATPDSS	DEG_SCF_FBW7_1	0.0833
p.S1235F	SIDM00672	Hepatocellular Carcinoma	GDSC	IATPDSS	DEG_SCF_FBW7_1	0.1111
p.S1235Y	SIDM00185	Melanoma	GDSC	IATPDSS	DEG_SCF_FBW7_1	0.1111
p.S1235Y	SIDM01650	Non-Cancerous	GDSC	IATPDSS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEY1	Neuron navigator 1	DEG_SCF_FBW7_1	1243:1249	IATPDSS	FBXW7	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons