DegronMD

Uniprot ID: Q8NEY1

Source protein: Neuron navigator 1

Source gene: NAV1

Class: DEG_SCF_FBW7_1

Location: 441:448

E3 ligase: FBXW7

DEGRON score: 0.9982

ASA_SCORE: 71.9375

COIL: 0.9055

CONS_SCORE: 0.5187

DSS_SCORE: 0.5214

HELIX: 0.0543

FCONS_SCORE: 1.0945

RIG_SCORE: 0.6192

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V455M	TCGA-78-7159	LUAD	TCGA	LPSTPTAS	DEG_SCF_FBW7_1	0.1389
p.R457C	TCGA-AZ-4315	COAD	TCGA	LPSTPTAS	DEG_SCF_FBW7_1	0.0833
p.S452L	TCGA-CU-A3KJ	BLCA	TCGA	LPSTPTAS	DEG_SCF_FBW7_1	0.6667
p.P445S	TCGA-YC-A89H	BLCA	TCGA	LPSTPTAS	DEG_SCF_FBW7_1	0.6752
p.S440C	SIDM00854	Burkitt's Lymphoma	GDSC	LPSTPTAS	DEG_SCF_FBW7_1	0.75
p.S440C	GA-10	haematopoietic_and_lymphoid_tissue	COSMIC	LPSTPTAS	DEG_SCF_FBW7_1	0.75
p.S453C	GA-10	haematopoietic_and_lymphoid_tissue	COSMIC	LPSTPTAS	DEG_SCF_FBW7_1	0.6389
p.L446I	SW900	lung	COSMIC	LPSTPTAS	DEG_SCF_FBW7_1	0.7174

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEY1	Neuron navigator 1	DEG_SCF_FBW7_1	441:448	LPSTPTAS	FBXW7	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons