DegronMD

Uniprot ID: Q8NEY1

Source protein: Neuron navigator 1

Source gene: NAV1

Class: DEG_COP1_1

Location: 900:907

E3 ligase: COP1

DEGRON score: 0.9498

ASA_SCORE: 90.65

COIL: 0.9766

CONS_SCORE: 0.3512

DSS_SCORE: 0.6966

HELIX: 0.009

FCONS_SCORE: 0.9248

RIG_SCORE: 0.5301

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V904I	SIDM00510	Small Cell Lung Carcinoma	GDSC	SSTPVPTP	DEG_COP1_1	0.7076
p.V904I	COR-L303	lung	COSMIC	SSTPVPTP	DEG_COP1_1	0.7076
p.S900N	TCGA-CC-A7IL	LIHC	TCGA	SSTPVPTP	DEG_COP1_1	0.7069
p.S900N	DO52185	LIHC	ICGC	SSTPVPTP	DEG_COP1_1	0.7069
p.T902A	DO228359	LICA	ICGC	SSTPVPTP	DEG_COP1_1	0.6028
p.S896I	DO229027	LICA	ICGC	SSTPVPTP	DEG_COP1_1	0.2222
p.S896T	SIDM01433	Kidney Carcinoma	GDSC	SSTPVPTP	DEG_COP1_1	0.2222
p.L894I	TCGA-AX-A1CE	UCEC	TCGA	SSTPVPTP	DEG_COP1_1	0.1667
p.L894I	DO42280	UCEC	ICGC	SSTPVPTP	DEG_COP1_1	0.1667
p.M892I	TCGA-AA-A010	COAD	TCGA	SSTPVPTP	DEG_COP1_1	0.1111
p.T915I	TCGA-D1-A15X	UCEC	TCGA	SSTPVPTP	DEG_COP1_1	0.1111
p.T915I	DO43274	UCEC	ICGC	SSTPVPTP	DEG_COP1_1	0.1111
p.M892V	DO234316	ESAD	ICGC	SSTPVPTP	DEG_COP1_1	0.1111
p.H892Y	DO219131	LUSC	ICGC	SSTPVPTP	DEG_COP1_1	0.1111
p.V917I	ACH-002095	Lung Cancer	CCLE	SSTPVPTP	DEG_COP1_1	0.0556
p.V917I	COR-L303	lung	COSMIC	SSTPVPTP	DEG_COP1_1	0.0556

Showing 1 to 16 of 16 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEY1	Neuron navigator 1	DEG_COP1_1	900:907	SSTPVPTP	COP1	0.9498	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons