DegronMD

Uniprot ID: Q6PRD1

Source protein: Probable G-protein coupled receptor 179

Source gene: GPR179

Class: DEG_SPOP_SBC_1

Location: 906:910

E3 ligase: SPOP

DEGRON score: 0.9545

ASA_SCORE: 99.74

COIL: 0.9402

CONS_SCORE: 0.5701

DSS_SCORE: 0.765

HELIX: 0.0294

FCONS_SCORE: 1.1233

RIG_SCORE: 0.4725

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A901V	TCGA-AA-A00N	COAD	TCGA	AKSSS	DEG_SPOP_SBC_1	0.1944
p.A901V	DO9876	COAD	ICGC	AKSSS	DEG_SPOP_SBC_1	0.1944
p.S904F	TCGA-EE-A29E	SKCM	TCGA	AKSSS	DEG_SPOP_SBC_1	0.2778
p.S904F	DO37831	SKCM	ICGC	AKSSS	DEG_SPOP_SBC_1	0.2778
p.R919G	TCGA-FI-A2D5	UCEC	TCGA	AKSSS	DEG_SPOP_SBC_1	0.0833
p.R919G	DO41331	UCEC	ICGC	AKSSS	DEG_SPOP_SBC_1	0.0833
p.V911M	TCGA-FU-A3TX	CESC	TCGA	AKSSS	DEG_SPOP_SBC_1	0.3056
p.V911M	DO44281	CESC	ICGC	AKSSS	DEG_SPOP_SBC_1	0.3056
p.V911M	DO52512	EOPC	ICGC	AKSSS	DEG_SPOP_SBC_1	0.3056
p.V911M	SIDM00720	Mesothelioma	GDSC	AKSSS	DEG_SPOP_SBC_1	0.3056
p.P903L	DO217950	ORCA	ICGC	AKSSS	DEG_SPOP_SBC_1	0.25
p.V911A	ACH-000961	Endometrial/Uterine Cancer	CCLE	AKSSS	DEG_SPOP_SBC_1	0.3056
p.V911E	ACH-001521	Skin Cancer	CCLE	AKSSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14647	Chromodomain-helicase-DNA-binding protein 2	DEG_SPOP_SBC_1	1432:1436	AKSSS	SPOP	0.9644	More...
O60885	Bromodomain-containing protein 4	DEG_SPOP_SBC_1	1217:1221	AKSSS	SPOP	0.9576	More...
O94762	ATP-dependent DNA helicase Q5	DEG_SPOP_SBC_1	732:736	AKSSS	SPOP	0.7563	More...
O95294	RasGAP-activating-like protein 1	DEG_SPOP_SBC_1	2:6	AKSSS	SPOP	0.7406	More...
P25440	Bromodomain-containing protein 2	DEG_SPOP_SBC_1	474:478	AKSSS	SPOP	0.6808	More...
Q14693	Phosphatidate phosphatase LPIN1	DEG_SPOP_SBC_1	282:286	AKSSS	SPOP	0.9674	More...
Q5VWN6	Protein TASOR 2	DEG_SPOP_SBC_1	1165:1169	AKSSS	SPOP	0.9726	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	755:759	AKSSS	SPOP	0.5292	More...
Q6PRD1	Probable G-protein coupled receptor 179	DEG_SPOP_SBC_1	906:910	AKSSS	SPOP	0.9545	More...
Q8NEY1	Neuron navigator 1	DEG_SPOP_SBC_1	677:681	AKSSS	SPOP	0.9854	More...
Q96PV6	Leukocyte receptor cluster member 8	DEG_SPOP_SBC_1	59:63	AKSSS	SPOP	0.9898	More...
Q9NWH9	SAFB-like transcription modulator	DEG_SPOP_SBC_1	351:355	AKSSS	SPOP	0.9894	More...
Q9NYV4	Cyclin-dependent kinase 12	DEG_SPOP_SBC_1	167:171	AKSSS	SPOP	0.989	More...
Q9P2N6	KAT8 regulatory NSL complex subunit 3	DEG_SPOP_SBC_1	698:702	AKSSS	SPOP	0.9382	More...
Q9Y692	Glucocorticoid modulatory element-binding protein 1	DEG_SPOP_SBC_1	455:459	AKSSS	SPOP	0.8751	More...
Q2TAC6	Kinesin-like protein KIF19	DEG_SPOP_SBC_1	720:724	AKSSS	SPOP	0.9422	More...
Q96BN6	Primary cilium assembly protein FAM149B1	DEG_SPOP_SBC_1	203:207	AKSSS	SPOP	0.9219	More...
Q5SYE7	NHS-like protein 1	DEG_SPOP_SBC_1	1146:1150	AKSSS	SPOP	0.9831	More...
Q6ZVL6	UPF0606 protein KIAA1549L	DEG_SPOP_SBC_1	676:680	AKSSS	SPOP	0.9984	More...
A6NCF6	Putative MAGE domain-containing protein MAGEA13P	DEG_SPOP_SBC_1	332:336	AKSSS	SPOP	0.9368	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AKSSS

Degron related mutations and impact score

Drug responses associated with GPR179 mutations

All proteins holding degron of AKSSS