DegronMD - Q6PRD1(GPR179)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1765E	TCGA-18-3409	LUSC	TCGA	PTPEWE	DEG_SCF_FBW7_2	1754:1759	Mutation rewiring degron network	0.1667
p.G1765E	DO26444	LUSC	ICGC	PTPEWE	DEG_SCF_FBW7_2	1754:1759	Mutation rewiring degron network	0.1667
p.A901V	TCGA-AA-A00N	COAD	TCGA	AKSSS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.1944
p.A901V	DO9876	COAD	ICGC	AKSSS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.1944
p.P1751S	TCGA-AB-2806	LAML	TCGA	PTPEWE	DEG_SCF_FBW7_2	1754:1759	Mutation rewiring degron network	0.25
p.P1751S	DO21283	LAML	ICGC	PTPEWE	DEG_SCF_FBW7_2	1754:1759	Mutation rewiring degron network	0.25
p.A975S	TCGA-BA-4077	HNSC	TCGA	LAPTPAPALAPVPV	DEG_ODPH_VHL_1	968:981	Mutation altering degron motif	0.6477
p.A975S	DO15647	HNSC	ICGC	LAPTPAPALAPVPV	DEG_ODPH_VHL_1	968:981	Mutation altering degron motif	0.6477
p.E1757Q	TCGA-CR-7388	HNSC	TCGA	PTPEWE	DEG_SCF_FBW7_2	1754:1759	Mutation altering degron motif	0.5633
p.E1757Q	DO14284	HNSC	ICGC	PTPEWE	DEG_SCF_FBW7_2	1754:1759	Mutation altering degron motif	0.5633
p.Y991C	TCGA-D1-A103	UCEC	TCGA	LAPTPAPALAPVPV	DEG_ODPH_VHL_1	968:981	Mutation rewiring degron network	0.0556
p.Y991C	DO42312	UCEC	ICGC	LAPTPAPALAPVPV	DEG_ODPH_VHL_1	968:981	Mutation rewiring degron network	0.0556
p.S904F	TCGA-EE-A29E	SKCM	TCGA	AKSSS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.2778
p.S904F	DO37831	SKCM	ICGC	AKSSS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.2778
p.E1591K	TCGA-EE-A2GD	SKCM	TCGA	AQEATPAK	DEG_SCF_SKP2-CKS1_1	1582:1589	Mutation rewiring degron network	0.2778
p.E1591K	DO37603	SKCM	ICGC	AQEATPAK	DEG_SCF_SKP2-CKS1_1	1582:1589	Mutation rewiring degron network	0.2778
p.A1588D	TCGA-EO-A3AV	UCEC	TCGA	AQEATPAK	DEG_SCF_SKP2-CKS1_1	1582:1589	Mutation altering degron motif	0.6682
p.A1588D	DO52412	UCEC	ICGC	AQEATPAK	DEG_SCF_SKP2-CKS1_1	1582:1589	Mutation altering degron motif	0.6682
p.R919G	TCGA-FI-A2D5	UCEC	TCGA	AKSSS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.0833
p.R919G	DO41331	UCEC	ICGC	AKSSS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.0833
p.A1588T	TCGA-FJ-A3Z7	BLCA	TCGA	AQEATPAK	DEG_SCF_SKP2-CKS1_1	1582:1589	Mutation altering degron motif	0.6028
p.A1588T	DO463	BLCA	ICGC	AQEATPAK	DEG_SCF_SKP2-CKS1_1	1582:1589	Mutation altering degron motif	0.6028
p.V911M	TCGA-FU-A3TX	CESC	TCGA	AKSSS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.3056
p.V911M	DO44281	CESC	ICGC	AKSSS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.3056
p.V911M	DO52512	EOPC	ICGC	AKSSS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.3056
p.V911M	SIDM00720	Mesothelioma	GDSC	AKSSS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.3056
p.L960S	DO233766	GACA	ICGC	LAPTPAPALAPVPV	DEG_ODPH_VHL_1	968:981	Mutation rewiring degron network	0.1111
p.P903L	DO217950	ORCA	ICGC	AKSSS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.25
p.E1749K	DO51506	PACA	ICGC	PTPEWE	DEG_SCF_FBW7_2	1754:1759	Mutation rewiring degron network	0.1944
p.P980T	SIDM02015	Colorectal Carcinoma	GDSC	LAPTPAPALAPVPV	DEG_ODPH_VHL_1	968:981	Mutation altering degron motif	0.5919
p.A975D	SIDM01265	Plasma Cell Myeloma	GDSC	LAPTPAPALAPVPV	DEG_ODPH_VHL_1	968:981	Mutation altering degron motif	0.6682
p.A975D	SIDM00845	Burkitt's Lymphoma	GDSC	LAPTPAPALAPVPV	DEG_ODPH_VHL_1	968:981	Mutation altering degron motif	0.6682
p.A975D	SIDM00878	Breast Carcinoma	GDSC	LAPTPAPALAPVPV	DEG_ODPH_VHL_1	968:981	Mutation altering degron motif	0.6682
p.A975D	SIDM00849	Kidney Carcinoma	GDSC	LAPTPAPALAPVPV	DEG_ODPH_VHL_1	968:981	Mutation altering degron motif	0.6682
p.A975D	SIDM00309	Mesothelioma	GDSC	LAPTPAPALAPVPV	DEG_ODPH_VHL_1	968:981	Mutation altering degron motif	0.6682
p.A975D	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	LAPTPAPALAPVPV	DEG_ODPH_VHL_1	968:981	Mutation altering degron motif	0.6682
p.A1582S	SIDM00118	Colorectal Carcinoma	GDSC	AQEATPAK	DEG_SCF_SKP2-CKS1_1	1582:1589	Mutation altering degron motif	0.6477
p.A1582S	ACH-001081	Colon/Colorectal Cancer	CCLE	AQEATPAK	DEG_SCF_SKP2-CKS1_1	1582:1589	Mutation altering degron motif	0.6477
p.V911A	ACH-000961	Endometrial/Uterine Cancer	CCLE	AKSSS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.3056
p.V911E	ACH-001521	Skin Cancer	CCLE	AKSSS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.3056
p.V1767L	ACH-002710	Sarcoma	CCLE	PTPEWE	DEG_SCF_FBW7_2	1754:1759	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GPR179

UniProt ID: Q6PRD1

Entrez ID: 440435

Protein name: Probable G-protein coupled receptor 179 (Probable G-protein coupled receptor 158-like 1) (GPR158-like)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GPR179 in