DegronMD

Uniprot ID: Q6PRD1

Source protein: Probable G-protein coupled receptor 179

Source gene: GPR179

Class: DEG_SCF_FBW7_2

Location: 1754:1759

E3 ligase: FBXW7

DEGRON score: 0.8933

ASA_SCORE: 103.0833

COIL: 0.8748

CONS_SCORE: 0.3986

DSS_SCORE: 0.5913

HELIX: 0.0895

FCONS_SCORE: 0.9051

RIG_SCORE: 0.7144

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1765E	TCGA-18-3409	LUSC	TCGA	PTPEWE	DEG_SCF_FBW7_2	0.1667
p.G1765E	DO26444	LUSC	ICGC	PTPEWE	DEG_SCF_FBW7_2	0.1667
p.P1751S	TCGA-AB-2806	LAML	TCGA	PTPEWE	DEG_SCF_FBW7_2	0.25
p.P1751S	DO21283	LAML	ICGC	PTPEWE	DEG_SCF_FBW7_2	0.25
p.E1757Q	TCGA-CR-7388	HNSC	TCGA	PTPEWE	DEG_SCF_FBW7_2	0.5633
p.E1757Q	DO14284	HNSC	ICGC	PTPEWE	DEG_SCF_FBW7_2	0.5633
p.E1749K	DO51506	PACA	ICGC	PTPEWE	DEG_SCF_FBW7_2	0.1944
p.V1767L	ACH-002710	Sarcoma	CCLE	PTPEWE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PRD1	Probable G-protein coupled receptor 179	DEG_SCF_FBW7_2	1754:1759	PTPEWE	FBXW7	0.8933	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons