DegronMD

Uniprot ID: Q6PRD1

Source protein: Probable G-protein coupled receptor 179

Source gene: GPR179

Class: DEG_ODPH_VHL_1

Location: 968:981

E3 ligase: VHL

DEGRON score: 0.7266

ASA_SCORE: 95.2714

COIL: 0.9545

CONS_SCORE: 0.4735

DSS_SCORE: 0.334

HELIX: 0.0185

FCONS_SCORE: 0.9157

RIG_SCORE: 0.6918

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A975S	TCGA-BA-4077	HNSC	TCGA	LAPTPAPALAPVPV	DEG_ODPH_VHL_1	0.6477
p.A975S	DO15647	HNSC	ICGC	LAPTPAPALAPVPV	DEG_ODPH_VHL_1	0.6477
p.Y991C	TCGA-D1-A103	UCEC	TCGA	LAPTPAPALAPVPV	DEG_ODPH_VHL_1	0.0556
p.Y991C	DO42312	UCEC	ICGC	LAPTPAPALAPVPV	DEG_ODPH_VHL_1	0.0556
p.L960S	DO233766	GACA	ICGC	LAPTPAPALAPVPV	DEG_ODPH_VHL_1	0.1111
p.P980T	SIDM02015	Colorectal Carcinoma	GDSC	LAPTPAPALAPVPV	DEG_ODPH_VHL_1	0.5919
p.A975D	SIDM01265	Plasma Cell Myeloma	GDSC	LAPTPAPALAPVPV	DEG_ODPH_VHL_1	0.6682
p.A975D	SIDM00845	Burkitt's Lymphoma	GDSC	LAPTPAPALAPVPV	DEG_ODPH_VHL_1	0.6682
p.A975D	SIDM00878	Breast Carcinoma	GDSC	LAPTPAPALAPVPV	DEG_ODPH_VHL_1	0.6682
p.A975D	SIDM00849	Kidney Carcinoma	GDSC	LAPTPAPALAPVPV	DEG_ODPH_VHL_1	0.6682
p.A975D	SIDM00309	Mesothelioma	GDSC	LAPTPAPALAPVPV	DEG_ODPH_VHL_1	0.6682
p.A975D	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	LAPTPAPALAPVPV	DEG_ODPH_VHL_1	0.6682

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PRD1	Probable G-protein coupled receptor 179	DEG_ODPH_VHL_1	968:981	LAPTPAPALAPVPV	VHL	0.7266	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons