DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
AQEATPAK
Uniprot ID:
Q6PRD1
Source protein:
Probable G-protein coupled receptor 179
Source gene:
GPR179
Class:
DEG_SCF_SKP2-CKS1_1
Location:
1582:1589
E3 ligase:
SKP2,CSK1
DEGRON score:
0.926
ASA_SCORE:
97.3375
COIL:
0.851
CONS_SCORE:
0.4531
DSS_SCORE:
0.5647
HELIX:
0.1189
FCONS_SCORE:
0.9853
RIG_SCORE:
0.7136
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A1588D
TCGA-EO-A3AV
UCEC
TCGA
AQEATPAK
DEG_SCF_SKP2-CKS1_1
0.6682
p.A1588D
DO52412
UCEC
ICGC
AQEATPAK
DEG_SCF_SKP2-CKS1_1
0.6682
p.A1582S
SIDM00118
Colorectal Carcinoma
GDSC
AQEATPAK
DEG_SCF_SKP2-CKS1_1
0.6477
p.A1582S
ACH-001081
Colon/Colorectal Cancer
CCLE
AQEATPAK
DEG_SCF_SKP2-CKS1_1
0.6477
p.A1588T
TCGA-FJ-A3Z7
BLCA
TCGA
AQEATPAK
DEG_SCF_SKP2-CKS1_1
0.6028
p.A1588T
DO463
BLCA
ICGC
AQEATPAK
DEG_SCF_SKP2-CKS1_1
0.6028
p.E1591K
TCGA-EE-A2GD
SKCM
TCGA
AQEATPAK
DEG_SCF_SKP2-CKS1_1
0.2778
p.E1591K
DO37603
SKCM
ICGC
AQEATPAK
DEG_SCF_SKP2-CKS1_1
0.2778
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Drug responses associated with GPR179 mutations
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Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of AQEATPAK
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6PRD1
Probable G-protein coupled receptor 179
DEG_SCF_SKP2-CKS1_1
1582:1589
AQEATPAK
SKP2,CSK1
0.926
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