DegronMD

Uniprot ID: Q6PRD1

Source protein: Probable G-protein coupled receptor 179

Source gene: GPR179

Class: DEG_SCF_SKP2-CKS1_1

Location: 1582:1589

E3 ligase: SKP2,CSK1

DEGRON score: 0.926

ASA_SCORE: 97.3375

COIL: 0.851

CONS_SCORE: 0.4531

DSS_SCORE: 0.5647

HELIX: 0.1189

FCONS_SCORE: 0.9853

RIG_SCORE: 0.7136

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1591K	TCGA-EE-A2GD	SKCM	TCGA	AQEATPAK	DEG_SCF_SKP2-CKS1_1	0.2778
p.E1591K	DO37603	SKCM	ICGC	AQEATPAK	DEG_SCF_SKP2-CKS1_1	0.2778
p.A1588D	TCGA-EO-A3AV	UCEC	TCGA	AQEATPAK	DEG_SCF_SKP2-CKS1_1	0.6682
p.A1588D	DO52412	UCEC	ICGC	AQEATPAK	DEG_SCF_SKP2-CKS1_1	0.6682
p.A1588T	TCGA-FJ-A3Z7	BLCA	TCGA	AQEATPAK	DEG_SCF_SKP2-CKS1_1	0.6028
p.A1588T	DO463	BLCA	ICGC	AQEATPAK	DEG_SCF_SKP2-CKS1_1	0.6028
p.A1582S	SIDM00118	Colorectal Carcinoma	GDSC	AQEATPAK	DEG_SCF_SKP2-CKS1_1	0.6477
p.A1582S	ACH-001081	Colon/Colorectal Cancer	CCLE	AQEATPAK	DEG_SCF_SKP2-CKS1_1	0.6477

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PRD1	Probable G-protein coupled receptor 179	DEG_SCF_SKP2-CKS1_1	1582:1589	AQEATPAK	SKP2,CSK1	0.926	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons