DegronMD - Q9Y692(GMEB1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P395S	TCGA-17-Z049	LUAD	TCGA	PASTT	DEG_SPOP_SBC_1	385:389	Mutation rewiring degron network	0.1667
p.R379W	TCGA-53-A4EZ	LUAD	TCGA	PASTT	DEG_SPOP_SBC_1	385:389	Mutation rewiring degron network	0.1667
p.R384W	TCGA-A6-6781	COAD	TCGA	PASTT	DEG_SPOP_SBC_1	385:389	Mutation rewiring degron network	0.3056
p.K375M	TCGA-AG-3896	READ	TCGA	PASTT	DEG_SPOP_SBC_1	385:389	Mutation substituting flanking lysine	0.1667
p.R447S	TCGA-AX-A2HC	UCEC	TCGA	AKSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1111
p.A386S	TCGA-AZ-6603	COAD	TCGA	PASTT	DEG_SPOP_SBC_1	385:389	Mutation altering degron motif	0.6477
p.T462P	TCGA-BT-A42C	BLCA	TCGA	AKSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.25
p.P396L	TCGA-D3-A2JF	SKCM	TCGA	PASTT	DEG_SPOP_SBC_1	385:389	Mutation rewiring degron network	0.1389
p.P396L	SIDM00936	Bladder Carcinoma	GDSC	PASTT	DEG_SPOP_SBC_1	385:389	Mutation rewiring degron network	0.1389
p.P396L	CAL-29	urinary tract	COSMIC	PASTT	DEG_SPOP_SBC_1	385:389	Mutation rewiring degron network	0.1389
p.H466Q	TCGA-E2-A1B6	BRCA	TCGA	AKSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1389
p.R447H	TCGA-EA-A3HS	CESC	TCGA	AKSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1111
p.R447H	SIDM00828	Other Sarcomas	GDSC	AKSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1111
p.R447H	SIDM00500	Colorectal Carcinoma	GDSC	AKSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1111
p.R447H	HT-1080	soft tissue	COSMIC	AKSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1111
p.S394P	TCGA-RC-A7SK	LIHC	TCGA	PASTT	DEG_SPOP_SBC_1	385:389	Mutation rewiring degron network	0.1944
p.T452P	DO49725	BLCA	ICGC	AKSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.25
p.A462V	DO52630	BOCA	ICGC	AKSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.25
p.P385T	DO224847	BRCA	ICGC	PASTT	DEG_SPOP_SBC_1	385:389	Mutation altering degron motif	0.7031
p.P385T	DO227473	BRCA	ICGC	PASTT	DEG_SPOP_SBC_1	385:389	Mutation altering degron motif	0.7031
p.H456Q	DO5493	BRCA	ICGC	AKSSS	DEG_SPOP_SBC_1	455:459	Mutation altering degron motif	0.7582
p.A376S	DO10188	COAD	ICGC	PASTT	DEG_SPOP_SBC_1	385:389	Mutation rewiring degron network	0.0833
p.S448I	DO229036	LICA	ICGC	AKSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1389
p.K446N	DO50917	LICA	ICGC	AKSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.0833
p.K446N	ACH-000769	Lung Cancer	CCLE	AKSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.0833
p.K446N	LK-2	lung	COSMIC	AKSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.0833
p.S384P	DO52314	LIHC	ICGC	PASTT	DEG_SPOP_SBC_1	385:389	Mutation rewiring degron network	0.3056
p.P386L	DO38153	SKCM	ICGC	PASTT	DEG_SPOP_SBC_1	385:389	Mutation altering degron motif	0.7582
p.P386L	ACH-000142	Bladder Cancer	CCLE	PASTT	DEG_SPOP_SBC_1	385:389	Mutation altering degron motif	0.7582
p.P386L	CAL-29	urinary tract	COSMIC	PASTT	DEG_SPOP_SBC_1	385:389	Mutation altering degron motif	0.7582
p.P390T	DO42673	UCEC	ICGC	PASTT	DEG_SPOP_SBC_1	385:389	Mutation rewiring degron network	0.3056
p.S458N	SIDM00845	Burkitt's Lymphoma	GDSC	AKSSS	DEG_SPOP_SBC_1	455:459	Mutation altering degron motif	0.7069
p.S458N	SIDM00461	Acute Myeloid Leukemia	GDSC	AKSSS	DEG_SPOP_SBC_1	455:459	Mutation altering degron motif	0.7069
p.S458N	SIDM01519	Head and Neck Carcinoma	GDSC	AKSSS	DEG_SPOP_SBC_1	455:459	Mutation altering degron motif	0.7069
p.K456N	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	AKSSS	DEG_SPOP_SBC_1	455:459	Mutation altering degron motif	0.5806
p.K456N	LK-2	lung	COSMIC	AKSSS	DEG_SPOP_SBC_1	455:459	Mutation altering degron motif	0.5806
p.R381Q	SIDM00217	Colorectal Carcinoma	GDSC	PASTT	DEG_SPOP_SBC_1	385:389	Mutation rewiring degron network	0.2222
p.R381Q	SIDM00220	Ovarian Carcinoma	GDSC	PASTT	DEG_SPOP_SBC_1	385:389	Mutation rewiring degron network	0.2222
p.R381Q	OC-314	ovary	COSMIC	PASTT	DEG_SPOP_SBC_1	385:389	Mutation rewiring degron network	0.2222
p.R381Q	SNU-1040	large intestine	COSMIC	PASTT	DEG_SPOP_SBC_1	385:389	Mutation rewiring degron network	0.2222
p.S448N	ACH-000992	Head and Neck Cancer	CCLE	AKSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1389

Kaplan plot for GMEB1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GMEB1

UniProt ID: Q9Y692

Entrez ID: 10691

Protein name: Glucocorticoid modulatory element-binding protein 1 (GMEB-1) (DNA-binding protein p96PIF) (Parvovirus initiation factor p96) (PIF p96)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GMEB1 in