DegronMD - Q96PV6(LENG8)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R525L	TCGA-39-5040	LUSC	TCGA	RRLRLEPLV	DEG_APCC_DBOX_1	522:530	Mutation altering degron motif	0.7316
p.R525L	DO45436	LUSC	ICGC	RRLRLEPLV	DEG_APCC_DBOX_1	522:530	Mutation altering degron motif	0.7316
p.E38K	TCGA-46-6026	LUSC	TCGA	ARQALASIS	DEG_APCC_DBOX_1	42:50	Mutation rewiring degron network	0.2222
p.P37T	TCGA-A5-A0G1	UCEC	TCGA	ARQALASIS	DEG_APCC_DBOX_1	42:50	Mutation rewiring degron network	0.1944
p.P37T	DO42472	UCEC	ICGC	ARQALASIS	DEG_APCC_DBOX_1	42:50	Mutation rewiring degron network	0.1944
p.R515H	TCGA-A5-A1OF	UCEC	TCGA	RRLRLEPLV	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.1389
p.R515H	DO42568	UCEC	ICGC	RRLRLEPLV	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.1389
p.R515H	DO41199	UCEC	ICGC	RRLRLEPLV	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.1389
p.R345Q	TCGA-A6-2686	COAD	TCGA	SREPLPGLT	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.3056
p.R345Q	DO7828	COAD	ICGC	SREPLPGLT	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.3056
p.R512W	TCGA-D5-6928	COAD	TCGA	RRLRLEPLV	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.0556
p.R512W	DO7776	COAD	ICGC	RRLRLEPLV	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.0556
p.R512W	DO232224	PBCA	ICGC	RRLRLEPLV	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.0556
p.R522H	TCGA-D5-6928	COAD	TCGA	RRLRLEPLV	DEG_APCC_DBOX_1	522:530	Mutation altering degron motif	0.7133
p.R522H	DO7776	COAD	ICGC	RRLRLEPLV	DEG_APCC_DBOX_1	522:530	Mutation altering degron motif	0.7133
p.R43S	TCGA-DA-A1I1	SKCM	TCGA	ARQALASIS	DEG_APCC_DBOX_1	42:50	Mutation altering degron motif	0.7427
p.R43S	DO37966	SKCM	ICGC	ARQALASIS	DEG_APCC_DBOX_1	42:50	Mutation altering degron motif	0.7427
p.R512L	TCGA-EE-A2M6	SKCM	TCGA	RRLRLEPLV	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.0556
p.R512L	TCGA-ER-A19P	SKCM	TCGA	RRLRLEPLV	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.0556
p.R512L	DO37976	SKCM	ICGC	RRLRLEPLV	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.0556
p.R512L	DO47623	SKCM	ICGC	RRLRLEPLV	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.0556
p.E35K	TCGA-EE-A3J5	SKCM	TCGA	ARQALASIS	DEG_APCC_DBOX_1	42:50	Mutation rewiring degron network	0.1389
p.E35K	DO47331	SKCM	ICGC	ARQALASIS	DEG_APCC_DBOX_1	42:50	Mutation rewiring degron network	0.1389
p.A47T	TCGA-EY-A1GO	UCEC	TCGA	ARQALASIS	DEG_APCC_DBOX_1	42:50	Mutation altering degron motif	0.6028
p.A47T	DO41392	UCEC	ICGC	ARQALASIS	DEG_APCC_DBOX_1	42:50	Mutation altering degron motif	0.6028
p.P32L	TCGA-F4-6463	COAD	TCGA	ARQALASIS	DEG_APCC_DBOX_1	42:50	Mutation rewiring degron network	0.0556
p.P32L	DO7958	COAD	ICGC	ARQALASIS	DEG_APCC_DBOX_1	42:50	Mutation rewiring degron network	0.0556
p.S52L	DO234198	ESAD	ICGC	ARQALASIS	DEG_APCC_DBOX_1	42:50	Mutation rewiring degron network	0.2778
p.S52L	DO234198	ESAD	ICGC	AKSSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.1389
p.G519R	DO234302	ESAD	ICGC	RRLRLEPLV	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.25
p.L48M	DO233885	GACA	ICGC	ARQALASIS	DEG_APCC_DBOX_1	42:50	Mutation altering degron motif	0.711
p.R337Q	DO233882	GACA	ICGC	SREPLPGLT	DEG_APCC_DBOX_1	336:344	Mutation altering degron motif	0.7329
p.D38N	DO26740	LUSC	ICGC	ARQALASIS	DEG_APCC_DBOX_1	42:50	Mutation rewiring degron network	0.2222
p.A70V	DO232224	PBCA	ICGC	AKSSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.1389
p.S69N	DO229268	THCA	ICGC	AKSSS	DEG_SPOP_SBC_1	59:63	Mutation blocking phosphorylation signal	0.6111
p.R525H	DO42673	UCEC	ICGC	RRLRLEPLV	DEG_APCC_DBOX_1	522:530	Mutation altering degron motif	0.7133
p.Q44H	DO42673	UCEC	ICGC	ARQALASIS	DEG_APCC_DBOX_1	42:50	Mutation altering degron motif	0.647
p.P66S	SIDM00435	Acute Myeloid Leukemia	GDSC	AKSSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.P66S	SIDM00612	Glioma	GDSC	AKSSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.P66S	SIDM01658	Unknown	GDSC	AKSSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.P66S	ACH-000369	Leukemia	CCLE	AKSSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.P66S	ACH-000598	Myeloma	CCLE	AKSSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.P66S	ACH-002257	Brain Cancer	CCLE	AKSSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.P66S	KINGS-1	central nervous system	COSMIC	AKSSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.P66S	MOLM-16	haematopoietic and lymphoid tissue	COSMIC	AKSSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.V530M	SIDM01197	Colorectal Carcinoma	GDSC	RRLRLEPLV	DEG_APCC_DBOX_1	522:530	Mutation altering degron motif	0.6097
p.V530M	ACH-000722	Colon/Colorectal Cancer	CCLE	RRLRLEPLV	DEG_APCC_DBOX_1	522:530	Mutation altering degron motif	0.6097
p.V530M	SNU-C1	large intestine	COSMIC	RRLRLEPLV	DEG_APCC_DBOX_1	522:530	Mutation altering degron motif	0.6097
p.R515C	SIDM00352	Ovarian Carcinoma	GDSC	RRLRLEPLV	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.1389
p.R515C	ACH-000719	Ovarian Cancer	CCLE	RRLRLEPLV	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.1389
p.R515C	RMG-I	ovary	COSMIC	RRLRLEPLV	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.1389
p.E350K	SIDM00501	Oral Cavity Carcinoma	GDSC	SREPLPGLT	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.1667
p.E350K	ACH-001332	Head and Neck Cancer	CCLE	SREPLPGLT	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.1667
p.E350K	BICR78	upper aerodigestive tract	COSMIC	SREPLPGLT	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.1667
p.S63I	SIDM00590	Oral Cavity Carcinoma	GDSC	AKSSS	DEG_SPOP_SBC_1	59:63	Mutation altering degron motif	0.8453
p.S63I	HSC-2	upper aerodigestive tract	COSMIC	AKSSS	DEG_SPOP_SBC_1	59:63	Mutation altering degron motif	0.8453
p.R523H	SIDM00085	Glioma	GDSC	RRLRLEPLV	DEG_APCC_DBOX_1	522:530	Mutation altering degron motif	0.8244
p.R523H	SIDM00279	Gastric Carcinoma	GDSC	RRLRLEPLV	DEG_APCC_DBOX_1	522:530	Mutation altering degron motif	0.8244
p.R523H	ACH-000225	Gastric Cancer	CCLE	RRLRLEPLV	DEG_APCC_DBOX_1	522:530	Mutation altering degron motif	0.8244
p.R523H	ACH-000655	Brain Cancer	CCLE	RRLRLEPLV	DEG_APCC_DBOX_1	522:530	Mutation altering degron motif	0.8244
p.R523H	SF268	central nervous system	COSMIC	RRLRLEPLV	DEG_APCC_DBOX_1	522:530	Mutation altering degron motif	0.8244
p.P66L	SIDM01608	Endometrial Carcinoma	GDSC	AKSSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.P66L	ACH-000990	Endometrial/Uterine Cancer	CCLE	AKSSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.G328D	ACH-000985	Colon/Colorectal Cancer	CCLE	SREPLPGLT	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.1111
p.G352S	U-118-MG	central nervous system	COSMIC	SREPLPGLT	DEG_APCC_DBOX_1	336:344	Mutation rewiring degron network	0.1111
p.P531S	NCI-H1876	lung	COSMIC	RRLRLEPLV	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.3056
p.A353T	KCL-22	haematopoietic and lymphoid tissue	COSMIC	SREPLPGLT	DEG_APCC_DBOX_1	336:344	Mutation substituting flanking lysine	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LENG8

UniProt ID: Q96PV6

Entrez ID: 114823

Protein name: Leukocyte receptor cluster member 8

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LENG8 in