DegronMD

Uniprot ID: Q96PV6

Source protein: Leukocyte receptor cluster member 8

Source gene: LENG8

Class: DEG_APCC_DBOX_1

Location: 336:344

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5332

ASA_SCORE: 62.2667

COIL: 0.6943

CONS_SCORE: 0.2123

DSS_SCORE: 0.506

HELIX: 0.1244

FCONS_SCORE: 0.9154

RIG_SCORE: 0.716

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R345Q	TCGA-A6-2686	COAD	TCGA	SREPLPGLT	DEG_APCC_DBOX_1	0.3056
p.R345Q	DO7828	COAD	ICGC	SREPLPGLT	DEG_APCC_DBOX_1	0.3056
p.R337Q	DO233882	GACA	ICGC	SREPLPGLT	DEG_APCC_DBOX_1	0.7329
p.E350K	SIDM00501	Oral Cavity Carcinoma	GDSC	SREPLPGLT	DEG_APCC_DBOX_1	0.1667
p.E350K	ACH-001332	Head and Neck Cancer	CCLE	SREPLPGLT	DEG_APCC_DBOX_1	0.1667
p.E350K	BICR78	upper_aerodigestive_tract	COSMIC	SREPLPGLT	DEG_APCC_DBOX_1	0.1667
p.G328D	ACH-000985	Colon/Colorectal Cancer	CCLE	SREPLPGLT	DEG_APCC_DBOX_1	0.1111
p.G352S	U-118-MG	central_nervous_system	COSMIC	SREPLPGLT	DEG_APCC_DBOX_1	0.1111
p.A353T	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	SREPLPGLT	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96PV6	Leukocyte receptor cluster member 8	DEG_APCC_DBOX_1	336:344	SREPLPGLT	APC,CDC20,FZR1	0.5332	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons