DegronMD

Uniprot ID: Q96PV6

Source protein: Leukocyte receptor cluster member 8

Source gene: LENG8

Class: DEG_APCC_DBOX_1

Location: 522:530

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7037

ASA_SCORE: 104.3556

COIL: 0.631

CONS_SCORE: 0.716

DSS_SCORE: 0.3706

HELIX: 0.2913

FCONS_SCORE: 1.1264

RIG_SCORE: 0.7624

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R523H	SIDM00085	Glioma	GDSC	RRLRLEPLV	DEG_APCC_DBOX_1	0.8244
p.R523H	SIDM00279	Gastric Carcinoma	GDSC	RRLRLEPLV	DEG_APCC_DBOX_1	0.8244
p.R523H	ACH-000225	Gastric Cancer	CCLE	RRLRLEPLV	DEG_APCC_DBOX_1	0.8244
p.R523H	ACH-000655	Brain Cancer	CCLE	RRLRLEPLV	DEG_APCC_DBOX_1	0.8244
p.R523H	SF268	central_nervous_system	COSMIC	RRLRLEPLV	DEG_APCC_DBOX_1	0.8244
p.R525L	TCGA-39-5040	LUSC	TCGA	RRLRLEPLV	DEG_APCC_DBOX_1	0.7316
p.R525L	DO45436	LUSC	ICGC	RRLRLEPLV	DEG_APCC_DBOX_1	0.7316
p.R522H	TCGA-D5-6928	COAD	TCGA	RRLRLEPLV	DEG_APCC_DBOX_1	0.7133
p.R522H	DO7776	COAD	ICGC	RRLRLEPLV	DEG_APCC_DBOX_1	0.7133
p.R525H	DO42673	UCEC	ICGC	RRLRLEPLV	DEG_APCC_DBOX_1	0.7133
p.V530M	SIDM01197	Colorectal Carcinoma	GDSC	RRLRLEPLV	DEG_APCC_DBOX_1	0.6097
p.V530M	ACH-000722	Colon/Colorectal Cancer	CCLE	RRLRLEPLV	DEG_APCC_DBOX_1	0.6097
p.V530M	SNU-C1	large_intestine	COSMIC	RRLRLEPLV	DEG_APCC_DBOX_1	0.6097
p.P531S	NCI-H1876	lung	COSMIC	RRLRLEPLV	DEG_APCC_DBOX_1	0.3056
p.G519R	DO234302	ESAD	ICGC	RRLRLEPLV	DEG_APCC_DBOX_1	0.25
p.R515H	TCGA-A5-A1OF	UCEC	TCGA	RRLRLEPLV	DEG_APCC_DBOX_1	0.1389
p.R515H	DO42568	UCEC	ICGC	RRLRLEPLV	DEG_APCC_DBOX_1	0.1389
p.R515H	DO41199	UCEC	ICGC	RRLRLEPLV	DEG_APCC_DBOX_1	0.1389
p.R515C	SIDM00352	Ovarian Carcinoma	GDSC	RRLRLEPLV	DEG_APCC_DBOX_1	0.1389
p.R515C	ACH-000719	Ovarian Cancer	CCLE	RRLRLEPLV	DEG_APCC_DBOX_1	0.1389
p.R515C	RMG-I	ovary	COSMIC	RRLRLEPLV	DEG_APCC_DBOX_1	0.1389
p.R512W	TCGA-D5-6928	COAD	TCGA	RRLRLEPLV	DEG_APCC_DBOX_1	0.0556
p.R512W	DO7776	COAD	ICGC	RRLRLEPLV	DEG_APCC_DBOX_1	0.0556
p.R512W	DO232224	PBCA	ICGC	RRLRLEPLV	DEG_APCC_DBOX_1	0.0556
p.R512L	TCGA-EE-A2M6	SKCM	TCGA	RRLRLEPLV	DEG_APCC_DBOX_1	0.0556

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Drug responses associated with LENG8 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of RRLRLEPLV

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96PV6	Leukocyte receptor cluster member 8	DEG_APCC_DBOX_1	522:530	RRLRLEPLV	APC,CDC20,FZR1	0.7037	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRLRLEPLV

Degron related mutations and impact score

Drug responses associated with LENG8 mutations

All proteins holding degron of RRLRLEPLV