DegronMD

Uniprot ID: Q96PV6

Source protein: Leukocyte receptor cluster member 8

Source gene: LENG8

Class: DEG_APCC_DBOX_1

Location: 522:530

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7037

ASA_SCORE: 104.3556

COIL: 0.631

CONS_SCORE: 0.716

DSS_SCORE: 0.3706

HELIX: 0.2913

FCONS_SCORE: 1.1264

RIG_SCORE: 0.7624

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R525L	TCGA-39-5040	LUSC	TCGA	RRLRLEPLV	DEG_APCC_DBOX_1	0.7316
p.R525L	DO45436	LUSC	ICGC	RRLRLEPLV	DEG_APCC_DBOX_1	0.7316
p.R515H	TCGA-A5-A1OF	UCEC	TCGA	RRLRLEPLV	DEG_APCC_DBOX_1	0.1389
p.R515H	DO42568	UCEC	ICGC	RRLRLEPLV	DEG_APCC_DBOX_1	0.1389
p.R515H	DO41199	UCEC	ICGC	RRLRLEPLV	DEG_APCC_DBOX_1	0.1389
p.R512W	TCGA-D5-6928	COAD	TCGA	RRLRLEPLV	DEG_APCC_DBOX_1	0.0556
p.R512W	DO7776	COAD	ICGC	RRLRLEPLV	DEG_APCC_DBOX_1	0.0556
p.R512W	DO232224	PBCA	ICGC	RRLRLEPLV	DEG_APCC_DBOX_1	0.0556
p.R522H	TCGA-D5-6928	COAD	TCGA	RRLRLEPLV	DEG_APCC_DBOX_1	0.7133
p.R522H	DO7776	COAD	ICGC	RRLRLEPLV	DEG_APCC_DBOX_1	0.7133
p.R512L	TCGA-EE-A2M6	SKCM	TCGA	RRLRLEPLV	DEG_APCC_DBOX_1	0.0556
p.R512L	TCGA-ER-A19P	SKCM	TCGA	RRLRLEPLV	DEG_APCC_DBOX_1	0.0556
p.R512L	DO37976	SKCM	ICGC	RRLRLEPLV	DEG_APCC_DBOX_1	0.0556
p.R512L	DO47623	SKCM	ICGC	RRLRLEPLV	DEG_APCC_DBOX_1	0.0556
p.G519R	DO234302	ESAD	ICGC	RRLRLEPLV	DEG_APCC_DBOX_1	0.25
p.R525H	DO42673	UCEC	ICGC	RRLRLEPLV	DEG_APCC_DBOX_1	0.7133
p.V530M	SIDM01197	Colorectal Carcinoma	GDSC	RRLRLEPLV	DEG_APCC_DBOX_1	0.6097
p.V530M	ACH-000722	Colon/Colorectal Cancer	CCLE	RRLRLEPLV	DEG_APCC_DBOX_1	0.6097
p.V530M	SNU-C1	large_intestine	COSMIC	RRLRLEPLV	DEG_APCC_DBOX_1	0.6097
p.R515C	SIDM00352	Ovarian Carcinoma	GDSC	RRLRLEPLV	DEG_APCC_DBOX_1	0.1389
p.R515C	ACH-000719	Ovarian Cancer	CCLE	RRLRLEPLV	DEG_APCC_DBOX_1	0.1389
p.R515C	RMG-I	ovary	COSMIC	RRLRLEPLV	DEG_APCC_DBOX_1	0.1389
p.R523H	SIDM00085	Glioma	GDSC	RRLRLEPLV	DEG_APCC_DBOX_1	0.8244
p.R523H	SIDM00279	Gastric Carcinoma	GDSC	RRLRLEPLV	DEG_APCC_DBOX_1	0.8244
p.R523H	ACH-000225	Gastric Cancer	CCLE	RRLRLEPLV	DEG_APCC_DBOX_1	0.8244
p.R523H	ACH-000655	Brain Cancer	CCLE	RRLRLEPLV	DEG_APCC_DBOX_1	0.8244
p.R523H	SF268	central_nervous_system	COSMIC	RRLRLEPLV	DEG_APCC_DBOX_1	0.8244
p.P531S	NCI-H1876	lung	COSMIC	RRLRLEPLV	DEG_APCC_DBOX_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRLRLEPLV

Degron related mutations and impact score

Drug responses associated with LENG8 mutations

All proteins holding degron of RRLRLEPLV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96PV6	Leukocyte receptor cluster member 8	DEG_APCC_DBOX_1	522:530	RRLRLEPLV	APC,CDC20,FZR1	0.7037	More...