DegronMD

Uniprot ID: Q96PV6

Source protein: Leukocyte receptor cluster member 8

Source gene: LENG8

Class: DEG_APCC_DBOX_1

Location: 42:50

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8471

ASA_SCORE: 58.5

COIL: 0.2821

CONS_SCORE: 0.2262

DSS_SCORE: 0.5581

HELIX: 0.7101

FCONS_SCORE: 0.9946

RIG_SCORE: 0.7457

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E38K	TCGA-46-6026	LUSC	TCGA	ARQALASIS	DEG_APCC_DBOX_1	0.2222
p.P37T	TCGA-A5-A0G1	UCEC	TCGA	ARQALASIS	DEG_APCC_DBOX_1	0.1944
p.P37T	DO42472	UCEC	ICGC	ARQALASIS	DEG_APCC_DBOX_1	0.1944
p.R43S	TCGA-DA-A1I1	SKCM	TCGA	ARQALASIS	DEG_APCC_DBOX_1	0.7427
p.R43S	DO37966	SKCM	ICGC	ARQALASIS	DEG_APCC_DBOX_1	0.7427
p.E35K	TCGA-EE-A3J5	SKCM	TCGA	ARQALASIS	DEG_APCC_DBOX_1	0.1389
p.E35K	DO47331	SKCM	ICGC	ARQALASIS	DEG_APCC_DBOX_1	0.1389
p.A47T	TCGA-EY-A1GO	UCEC	TCGA	ARQALASIS	DEG_APCC_DBOX_1	0.6028
p.A47T	DO41392	UCEC	ICGC	ARQALASIS	DEG_APCC_DBOX_1	0.6028
p.P32L	TCGA-F4-6463	COAD	TCGA	ARQALASIS	DEG_APCC_DBOX_1	0.0556
p.P32L	DO7958	COAD	ICGC	ARQALASIS	DEG_APCC_DBOX_1	0.0556
p.S52L	DO234198	ESAD	ICGC	ARQALASIS	DEG_APCC_DBOX_1	0.2778
p.L48M	DO233885	GACA	ICGC	ARQALASIS	DEG_APCC_DBOX_1	0.711
p.D38N	DO26740	LUSC	ICGC	ARQALASIS	DEG_APCC_DBOX_1	0.2222
p.Q44H	DO42673	UCEC	ICGC	ARQALASIS	DEG_APCC_DBOX_1	0.647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96PV6	Leukocyte receptor cluster member 8	DEG_APCC_DBOX_1	42:50	ARQALASIS	APC,CDC20,FZR1	0.8471	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons