DegronMD

Uniprot ID: Q2TAC6

Source protein: Kinesin-like protein KIF19

Source gene: KIF19

Class: DEG_ODPH_VHL_1

Location: 801:812

E3 ligase: VHL

DEGRON score: 0.8895

ASA_SCORE: 79.6917

COIL: 0.7793

CONS_SCORE: 0.337

DSS_SCORE: 0.5272

HELIX: 0.1762

FCONS_SCORE: 1.0301

RIG_SCORE: 0.6637

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R807H	DO229010	COCA	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.7133
p.R807H	DO229013	COCA	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.7133
p.R807H	DO229016	COCA	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.7133
p.R807H	DO229003	COCA	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.7133
p.R807H	DO229005	COCA	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.7133
p.R807H	DO229489	LAML	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.7133
p.R807H	DO229053	LICA	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.7133
p.S811C	TCGA-46-6026	LUSC	TCGA	LAPATERSSLSL	DEG_ODPH_VHL_1	0.643
p.S811C	DO26740	LUSC	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.643
p.A804T	DO222485	COCA	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.6028
p.S808T	ACH-000621	Breast Cancer	CCLE	LAPATERSSLSL	DEG_ODPH_VHL_1	0.6005
p.L812M	TCGA-91-6829	LUAD	TCGA	LAPATERSSLSL	DEG_ODPH_VHL_1	0.5999
p.L812M	DO23564	LUAD	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.5999
p.H813P	ACH-000871	Lung Cancer	CCLE	LAPATERSSLSL	DEG_ODPH_VHL_1	0.3056
p.H813P	NCI-H510A	lung	COSMIC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.3056
p.R798P	SIDM00273	Glioblastoma	GDSC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.25
p.R798P	ACH-000756	Brain Cancer	CCLE	LAPATERSSLSL	DEG_ODPH_VHL_1	0.25
p.R798P	GI-1	central_nervous_system	COSMIC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.25
p.S816N	TCGA-WE-AAA3	SKCM	TCGA	LAPATERSSLSL	DEG_ODPH_VHL_1	0.2222
p.S816N	DO51295	SKCM	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.2222
p.E817K	TCGA-44-5644	LUAD	TCGA	LAPATERSSLSL	DEG_ODPH_VHL_1	0.1944
p.E817K	DO25153	LUAD	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.1944
p.T795P	TCGA-CG-5727	STAD	TCGA	LAPATERSSLSL	DEG_ODPH_VHL_1	0.1667
p.T795P	DO38511	STAD	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.1667
p.L793V	TCGA-63-A5MH	LUSC	TCGA	LAPATERSSLSL	DEG_ODPH_VHL_1	0.1111

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Drug responses associated with KIF19 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of LAPATERSSLSL

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2TAC6	Kinesin-like protein KIF19	DEG_ODPH_VHL_1	801:812	LAPATERSSLSL	VHL	0.8895	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPATERSSLSL

Degron related mutations and impact score

Drug responses associated with KIF19 mutations

All proteins holding degron of LAPATERSSLSL