DegronMD

Uniprot ID: Q2TAC6

Source protein: Kinesin-like protein KIF19

Source gene: KIF19

Class: DEG_ODPH_VHL_1

Location: 801:812

E3 ligase: VHL

DEGRON score: 0.8895

ASA_SCORE: 79.6917

COIL: 0.7793

CONS_SCORE: 0.337

DSS_SCORE: 0.5272

HELIX: 0.1762

FCONS_SCORE: 1.0301

RIG_SCORE: 0.6637

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E817K	TCGA-44-5644	LUAD	TCGA	LAPATERSSLSL	DEG_ODPH_VHL_1	0.1944
p.E817K	DO25153	LUAD	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.1944
p.S811C	TCGA-46-6026	LUSC	TCGA	LAPATERSSLSL	DEG_ODPH_VHL_1	0.643
p.S811C	DO26740	LUSC	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.643
p.L793V	TCGA-63-A5MH	LUSC	TCGA	LAPATERSSLSL	DEG_ODPH_VHL_1	0.1111
p.L793V	DO219146	LUSC	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.1111
p.L812M	TCGA-91-6829	LUAD	TCGA	LAPATERSSLSL	DEG_ODPH_VHL_1	0.5999
p.L812M	DO23564	LUAD	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.5999
p.T795P	TCGA-CG-5727	STAD	TCGA	LAPATERSSLSL	DEG_ODPH_VHL_1	0.1667
p.T795P	DO38511	STAD	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.1667
p.A821T	TCGA-EK-A3GK	CESC	TCGA	LAPATERSSLSL	DEG_ODPH_VHL_1	0.0833
p.A821T	DO49964	CESC	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.0833
p.S816N	TCGA-WE-AAA3	SKCM	TCGA	LAPATERSSLSL	DEG_ODPH_VHL_1	0.2222
p.S816N	DO51295	SKCM	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.2222
p.R791W	TCGA-ZF-A9RC	BLCA	TCGA	LAPATERSSLSL	DEG_ODPH_VHL_1	0.0556
p.R791W	DO219068	BLCA	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.0556
p.R791W	DO228299	LICA	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.0556
p.A804T	DO222485	COCA	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.6028
p.R807H	DO229010	COCA	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.7133
p.R807H	DO229013	COCA	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.7133
p.R807H	DO229016	COCA	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.7133
p.R807H	DO229003	COCA	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.7133
p.R807H	DO229005	COCA	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.7133
p.R807H	DO229489	LAML	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.7133
p.R807H	DO229053	LICA	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.7133
p.R798P	SIDM00273	Glioblastoma	GDSC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.25
p.R798P	ACH-000756	Brain Cancer	CCLE	LAPATERSSLSL	DEG_ODPH_VHL_1	0.25
p.R798P	GI-1	central_nervous_system	COSMIC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.25
p.S808T	ACH-000621	Breast Cancer	CCLE	LAPATERSSLSL	DEG_ODPH_VHL_1	0.6005
p.H813P	ACH-000871	Lung Cancer	CCLE	LAPATERSSLSL	DEG_ODPH_VHL_1	0.3056
p.H813P	NCI-H510A	lung	COSMIC	LAPATERSSLSL	DEG_ODPH_VHL_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPATERSSLSL

Degron related mutations and impact score

Drug responses associated with KIF19 mutations

All proteins holding degron of LAPATERSSLSL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2TAC6	Kinesin-like protein KIF19	DEG_ODPH_VHL_1	801:812	LAPATERSSLSL	VHL	0.8895	More...