DegronMD

Uniprot ID: Q2TAC6

Source protein: Kinesin-like protein KIF19

Source gene: KIF19

Class: DEG_SCF_FBW7_1

Location: 665:672

E3 ligase: FBXW7

DEGRON score: 0.9983

ASA_SCORE: 78.475

COIL: 0.9158

CONS_SCORE: 0.3603

DSS_SCORE: 0.5631

HELIX: 0.0251

FCONS_SCORE: 1.0556

RIG_SCORE: 0.6513

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P669L	TCGA-BF-AAOU	SKCM	TCGA	PKITPAGT	DEG_SCF_FBW7_1	0.7582
p.P669L	DO219460	SKCM	ICGC	PKITPAGT	DEG_SCF_FBW7_1	0.7582
p.L680M	TCGA-ER-A1A1	SKCM	TCGA	PKITPAGT	DEG_SCF_FBW7_1	0.1111
p.L680M	DO37413	SKCM	ICGC	PKITPAGT	DEG_SCF_FBW7_1	0.1111
p.A670T	TCGA-KN-8427	KICH	TCGA	PKITPAGT	DEG_SCF_FBW7_1	0.6028
p.A670T	DO220479	KICH	ICGC	PKITPAGT	DEG_SCF_FBW7_1	0.6028
p.S663C	TCGA-MT-A67F	HNSC	TCGA	PKITPAGT	DEG_SCF_FBW7_1	0.2778
p.S663C	DO49070	HNSC	ICGC	PKITPAGT	DEG_SCF_FBW7_1	0.2778
p.K666N	DO8264	COAD	ICGC	PKITPAGT	DEG_SCF_FBW7_1	0.5806
p.S662I	DO229022	LICA	ICGC	PKITPAGT	DEG_SCF_FBW7_1	0.25
p.A670E	DO231837	LINC	ICGC	PKITPAGT	DEG_SCF_FBW7_1	0.659
p.S662C	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	PKITPAGT	DEG_SCF_FBW7_1	0.25
p.S662C	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	PKITPAGT	DEG_SCF_FBW7_1	0.25
p.T675P	ACH-000993	Endometrial/Uterine Cancer	CCLE	PKITPAGT	DEG_SCF_FBW7_1	0.6944
p.R657K	ACH-002396	Bone Cancer	CCLE	PKITPAGT	DEG_SCF_FBW7_1	0.1111
p.R657K	Sarc9371	bone	COSMIC	PKITPAGT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2TAC6	Kinesin-like protein KIF19	DEG_SCF_FBW7_1	665:672	PKITPAGT	FBXW7	0.9983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons