DegronMD

Uniprot ID: Q96CP6

Source protein: Protein Aster-A

Source gene: GRAMD1A

Class: DEG_SCF_FBW7_1

Location: 276:281

E3 ligase: FBXW7

DEGRON score: 0.9914

ASA_SCORE: 78.1167

COIL: 0.7765

CONS_SCORE: 0.2618

DSS_SCORE: 0.7377

HELIX: 0.148

FCONS_SCORE: 0.9875

RIG_SCORE: 0.6006

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S284G	TCGA-18-5595	LUSC	TCGA	VTPNLS	DEG_SCF_FBW7_1	0.25
p.S284I	TCGA-18-5595	LUSC	TCGA	VTPNLS	DEG_SCF_FBW7_1	0.25
p.S284I	TCGA-CI-6624	READ	TCGA	VTPNLS	DEG_SCF_FBW7_1	0.25
p.P278S	TCGA-AD-6889	COAD	TCGA	VTPNLS	DEG_SCF_FBW7_1	0.6752
p.A287T	TCGA-AX-A2HD	UCEC	TCGA	VTPNLS	DEG_SCF_FBW7_1	0.1667
p.A287T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VTPNLS	DEG_SCF_FBW7_1	0.1667
p.A287T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VTPNLS	DEG_SCF_FBW7_1	0.1667
p.D288H	TCGA-AX-A2IO	UCEC	TCGA	VTPNLS	DEG_SCF_FBW7_1	0.1389
p.E288Q	DO856	BLCA	ICGC	VTPNLS	DEG_SCF_FBW7_1	0.1389
p.R280H	DO219869	LGG	ICGC	VTPNLS	DEG_SCF_FBW7_1	0.8244
p.R280H	DO228138	PBCA	ICGC	VTPNLS	DEG_SCF_FBW7_1	0.8244
p.G269E	DO222542	MELA	ICGC	VTPNLS	DEG_SCF_FBW7_1	0.1389
p.R273H	DO27927	ORCA	ICGC	VTPNLS	DEG_SCF_FBW7_1	0.25
p.R273C	DO47985	STAD	ICGC	VTPNLS	DEG_SCF_FBW7_1	0.25
p.F268S	DO48174	UCEC	ICGC	VTPNLS	DEG_SCF_FBW7_1	0.1111
p.D286N	SIDM01300	Colorectal Carcinoma	GDSC	VTPNLS	DEG_SCF_FBW7_1	0.1944
p.D286N	SIDM00665	Gastric Carcinoma	GDSC	VTPNLS	DEG_SCF_FBW7_1	0.1944
p.D286N	Hs746T	stomach	COSMIC	VTPNLS	DEG_SCF_FBW7_1	0.1944
p.S271L	SIDM00889	Cervical Carcinoma	GDSC	VTPNLS	DEG_SCF_FBW7_1	0.6389
p.S271L	C-33-A	cervix	COSMIC	VTPNLS	DEG_SCF_FBW7_1	0.6389
p.R272C	SIDM01131	Small Cell Lung Carcinoma	GDSC	VTPNLS	DEG_SCF_FBW7_1	0.2222
p.D287N	ACH-000969	Colon/Colorectal Cancer	CCLE	VTPNLS	DEG_SCF_FBW7_1	0.1667
p.D287N	KM12	large_intestine	COSMIC	VTPNLS	DEG_SCF_FBW7_1	0.1667
p.R275Q	ACH-001414	Bladder Cancer	CCLE	VTPNLS	DEG_SCF_FBW7_1	0.3056
p.A280T	ACH-002256	Leukemia	CCLE	VTPNLS	DEG_SCF_FBW7_1	0.7139
p.A280T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VTPNLS	DEG_SCF_FBW7_1	0.7139
p.D279N	Hs746T	stomach	COSMIC	VTPNLS	DEG_SCF_FBW7_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96CP6	Protein Aster-A	DEG_SCF_FBW7_1	276:281	VTPNLS	FBXW7	0.9914	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTPNLS

Degron related mutations and impact score

Drug responses associated with GRAMD1A mutations

All proteins holding degron of VTPNLS