DegronMD

Uniprot ID: Q96CP6

Source protein: Protein Aster-A

Source gene: GRAMD1A

Class: DEG_APCC_DBOX_1

Location: 545:553

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9268

ASA_SCORE: 92.6556

COIL: 0.6927

CONS_SCORE: 0.2449

DSS_SCORE: 0.5039

HELIX: 0.2744

FCONS_SCORE: 0.9692

RIG_SCORE: 0.7034

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L538V	TCGA-2H-A9GF	ESCA	TCGA	ARGLLSGLR	DEG_APCC_DBOX_1	0.1389
p.R562L	TCGA-56-8083	LUSC	TCGA	ARGLLSGLR	DEG_APCC_DBOX_1	0.0833
p.R555W	TCGA-A5-A0G2	UCEC	TCGA	ARGLLSGLR	DEG_APCC_DBOX_1	0.2778
p.R546L	TCGA-DJ-A2QB	THCA	TCGA	ARGLLSGLR	DEG_APCC_DBOX_1	0.8428
p.S537F	TCGA-ER-A19D	SKCM	TCGA	ARGLLSGLR	DEG_APCC_DBOX_1	0.1111
p.R553Q	TCGA-NC-A5HJ	LUSC	TCGA	ARGLLSGLR	DEG_APCC_DBOX_1	0.6218
p.T551M	DO49806	BLCA	ICGC	ARGLLSGLR	DEG_APCC_DBOX_1	0.7423
p.T551M	DO233944	GACA	ICGC	ARGLLSGLR	DEG_APCC_DBOX_1	0.7423
p.T551M	GP5d	large_intestine	COSMIC	ARGLLSGLR	DEG_APCC_DBOX_1	0.7423
p.R536H	DO219072	BLCA	ICGC	ARGLLSGLR	DEG_APCC_DBOX_1	0.0833
p.G542W	DO10582	COAD	ICGC	ARGLLSGLR	DEG_APCC_DBOX_1	0.25
p.G542W	DO229031	LICA	ICGC	ARGLLSGLR	DEG_APCC_DBOX_1	0.25
p.G542W	DO229008	LICA	ICGC	ARGLLSGLR	DEG_APCC_DBOX_1	0.25
p.R535W	DO234285	ESAD	ICGC	ARGLLSGLR	DEG_APCC_DBOX_1	0.5
p.Q539H	DO233272	GACA	ICGC	ARGLLSGLR	DEG_APCC_DBOX_1	0.1667
p.I554N	DO228934	LICA	ICGC	ARGLLSGLR	DEG_APCC_DBOX_1	0.3056
p.I554N	COLO-792	skin	COSMIC	ARGLLSGLR	DEG_APCC_DBOX_1	0.3056
p.D558Y	DO229025	LICA	ICGC	ARGLLSGLR	DEG_APCC_DBOX_1	0.1944
p.S547F	DO220860	MELA	ICGC	ARGLLSGLR	DEG_APCC_DBOX_1	0.7982
p.Y561C	DO232224	PBCA	ICGC	ARGLLSGLR	DEG_APCC_DBOX_1	0.1111
p.Y559C	DO232532	PBCA	ICGC	ARGLLSGLR	DEG_APCC_DBOX_1	0.1667
p.R536C	DO51407	PRAD	ICGC	ARGLLSGLR	DEG_APCC_DBOX_1	0.0833
p.R536C	DO41871	UCEC	ICGC	ARGLLSGLR	DEG_APCC_DBOX_1	0.0833
p.G542R	DO47667	SKCM	ICGC	ARGLLSGLR	DEG_APCC_DBOX_1	0.25
p.G542R	SIDM00998	Glioblastoma	GDSC	ARGLLSGLR	DEG_APCC_DBOX_1	0.25
p.G542R	8-MG-BA	central_nervous_system	COSMIC	ARGLLSGLR	DEG_APCC_DBOX_1	0.25
p.S560N	SIDM00908	Non-Cancerous	GDSC	ARGLLSGLR	DEG_APCC_DBOX_1	0.5833
p.S560N	SIDM00909	Melanoma	GDSC	ARGLLSGLR	DEG_APCC_DBOX_1	0.5833
p.G541S	SIDM00006	Other Solid Cancers	GDSC	ARGLLSGLR	DEG_APCC_DBOX_1	0.2222
p.G541S	LNCaP-Clone-FGC	prostate	COSMIC	ARGLLSGLR	DEG_APCC_DBOX_1	0.2222
p.G541S	MCC26	skin	COSMIC	ARGLLSGLR	DEG_APCC_DBOX_1	0.2222
p.G541D	SIDM00006	Other Solid Cancers	GDSC	ARGLLSGLR	DEG_APCC_DBOX_1	0.2222
p.G541D	MCC26	skin	COSMIC	ARGLLSGLR	DEG_APCC_DBOX_1	0.2222
p.G535R	ACH-000137	Brain Cancer	CCLE	ARGLLSGLR	DEG_APCC_DBOX_1	0.5
p.G535R	8-MG-BA	central_nervous_system	COSMIC	ARGLLSGLR	DEG_APCC_DBOX_1	0.5
p.S553N	ACH-000644	Skin Cancer	CCLE	ARGLLSGLR	DEG_APCC_DBOX_1	0.7069
p.S553N	ACH-002380	Non-Cancerous	CCLE	ARGLLSGLR	DEG_APCC_DBOX_1	0.7069
p.P561S	ACH-000987	Skin Cancer	CCLE	ARGLLSGLR	DEG_APCC_DBOX_1	0.1111
p.P561S	Mewo	skin	COSMIC	ARGLLSGLR	DEG_APCC_DBOX_1	0.1111
p.G558W	ACH-000994	Endometrial/Uterine Cancer	CCLE	ARGLLSGLR	DEG_APCC_DBOX_1	0.1944
p.D537A	ACH-002659	Colon/Colorectal Cancer	CCLE	ARGLLSGLR	DEG_APCC_DBOX_1	0.1111
p.I554V	COLO-792	skin	COSMIC	ARGLLSGLR	DEG_APCC_DBOX_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARGLLSGLR

Degron related mutations and impact score

Drug responses associated with GRAMD1A mutations

All proteins holding degron of ARGLLSGLR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96CP6	Protein Aster-A	DEG_APCC_DBOX_1	545:553	ARGLLSGLR	APC,CDC20,FZR1	0.9268	More...